NDUFA6 Activators
NDUFA6 activators are a class of chemical compounds that play a crucial role in the regulation and enhancement of the NDUFA6 protein's activity within the mitochondria. NDUFA6, or NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6, is a subunit of the mitochondrial respiratory chain complex I, also known as NADH:ubiquinone oxidoreductase. This complex is a central component of the electron transport chain, responsible for transferring electrons from NADH to ubiquinone, a critical step in oxidative phosphorylation, the process by which cells generate adenosine triphosphate (ATP) to meet their energy needs.
NDUFA6 activators are designed to modulate the function of NDUFA6, thus influencing the efficiency of complex I and, subsequently, the overall cellular energy production. These activators typically work by binding to NDUFA6, either directly or indirectly, and stimulating its activity. By doing so, they facilitate the transfer of electrons along the mitochondrial electron transport chain, ultimately leading to a higher production of ATP. This enhanced ATP production can have far-reaching consequences for cellular functions, as ATP serves as the primary energy currency of the cell, vital for processes like muscle contraction, nerve impulse transmission, and various biochemical reactions. Additionally, a well-functioning mitochondrial electron transport chain is crucial for maintaining cellular redox balance and preventing the buildup of harmful reactive oxygen species (ROS).
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dehydroacetic acid | 520-45-6 | sc-239657 | 100 g | $52.00 | ||
Similar to rotenone, piericidin A is an inhibitor of mitochondrial complex I. Its action affects the function of the entire complex, including NDUFA6. By inhibiting complex I, it can indirectly activate NDUFA6 by disrupting its role in electron transfer within the complex. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $290.00 | ||
MitoQ is a mitochondria-targeted antioxidant. While it doesn't directly activate NDUFA6, its antioxidant properties may help protect mitochondrial function, including complex I, from oxidative damage. By preserving the integrity of complex I, it indirectly increases NDUFA6 activity within the complex. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 is an essential component of the electron transport chain and is involved in complex I. It helps shuttle electrons and protons within the chain. While it doesn't directly activate NDUFA6, its presence is crucial for the overall function of complex I, indirectly supporting NDUFA6's role in electron transfer. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol found in red grapes and other foods. It has been studied for its potential effects on mitochondrial function and oxidative stress. While it may indirectly increase mitochondrial health, its specific interaction with NDUFA6 is not well-defined, but it could indirectly enhance NDUFA6 function through its impact on mitochondrial health. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea and has antioxidant properties. While it may help protect mitochondria from oxidative damage, its direct interaction with NDUFA6 is not clear. Indirectly, it may increase NDUFA6 activity by preserving mitochondrial health through its antioxidant effects. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid is an antioxidant that can support mitochondrial health. It may indirectly increase NDUFA6 activity by protecting mitochondrial components from oxidative stress. By reducing oxidative damage within mitochondria, it indirectly contributes to NDUFA6's optimal function within complex I. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $59.00 | 2 | |
DNP is an uncoupling agent that disrupts the proton gradient across the mitochondrial inner membrane, impacting ATP production. It doesn't directly activate NDUFA6, but by altering mitochondrial function, it indirectly increases NDUFA6 activity within complex I due to changes in the electrochemical gradient. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin, a diabetes agent in research, has been studied for potential effects on mitochondrial function, but its precise interaction with NDUFA6 is not well-documented. It may indirectly increase NDUFA6 activity by modulating mitochondrial function, although the specific mechanism remains unclear. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is a natural compound with potential effects on mitochondrial function and cellular energy production. Its specific interaction with NDUFA6 is not well-understood. It might indirectly increase NDUFA6 activity by influencing mitochondrial energy production and function. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
NR is a precursor to NAD+ (nicotinamide adenine dinucleotide), which is involved in mitochondrial energy production. NR may indirectly activate NDUFA6 by influencing NAD+ levels. NAD+ is essential for proper electron transfer within complex I, indirectly activating NDUFA6 in its role. | ||||||