NDRG4 (N-myc downstream regulated gene 4) activators represent a group of chemical compounds that elevate the expression or activity of the NDRG4 protein. NDRG4 is a member of the NDRG family, which encompasses four known members (NDRG1-4). These proteins participate in a myriad of cellular functions such as cellular differentiation, growth, and various stress responses. Particularly, NDRG4 has found its significance in the realm of brain and heart development, with its expression being especially pronounced in brain tissues, including the cerebellum.
NDRG4 Activators are primarily characterized by their ability to augment the NDRG4 protein's expression or functional activity. These activators may act on a transcriptional level, enhancing the gene's transcription to produce more of the protein. Alternatively, they might operate on a post-transcriptional level, such as by increasing the protein's stability, thus prolonging its presence and action within the cell. Another mode of action could be enhancing the protein's activation state through post-translational modifications. The exact mechanism would depend on the specific chemical nature of the activator and its interaction with cellular pathways. Compounds that are known to influence broader cellular pathways, like the Wnt signaling or those involved in oxidative stress responses, serves as NDRG4 activators as these pathways have downstream effects on NDRG4. Recognizing and understanding these activators is pivotal for researchers aiming to dissect the nuanced regulatory networks of the cell, especially concerning the crucial pathways and processes that NDRG4 is known to influence.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences numerous genes by binding to its receptors. It could possibly influence NDRG4 expression among its broad target genes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels. Elevated cAMP can activate protein kinase A, influencing various genes, which might include NDRG4. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
This glucocorticoid can influence gene expression when it binds to its receptor, potentially affecting the expression of genes like NDRG4. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As an estrogen, it binds to estrogen receptors and can lead to the modulation of gene expression, which may include genes like NDRG4. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to have various cellular effects, including influencing signaling pathways and gene expression, which might impact the expression of NDRG4. | ||||||