NDRG4 Antibody (C-8): sc-514144
- NDRG4 Antibody (C-8) is a mouse monoclonal IgG2b λ NDRG4 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 170-192 within an internal region of NDRG4 of human origin
- NDRG4 Antibody (C-8) is recommended for detection of NDRG4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NDRG4 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGλ BP-HRP are the preferred secondary detection reagents for NDRG4 Antibody (C-8) for WB applications. These reagents are now offered in bundles with NDRG4 Antibody (C-8) (see ordering information below).
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NDRG4 Antibody (C-8) is a mouse monoclonal IgG2b antibody that detects NDRG4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-NDRG4 antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NDRG4 protein, also known as SMAP-8 or BDM1, is a 352 amino acid cytoplasmic protein that plays a crucial role in regulating mitogenic signaling pathways, particularly in vascular smooth muscle cells. NDRG4 expression is primarily localized in the brain and heart, highlighting its importance in these tissues. NDRG4 is involved in early postnatal development and mediates the differentiation and functional maturation of neuronal cells, which is vital for proper brain function and development. Additionally, NDRG4 is expressed as six isoforms due to alternative splicing, with the first three designated as NDRG4-BVar, NDRG4-B, and NDRG4-H, allowing for functional diversity and regulation in various cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NDRG4 Antibody (C-8) References:
- Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. | Zhou, RH., et al. 2001. Genomics. 73: 86-97. PMID: 11352569
- Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. | Qu, X., et al. 2002. Mol Cell Biochem. 229: 35-44. PMID: 11936845
- Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells. | Ohki, T., et al. 2002. Brain Res Dev Brain Res. 135: 55-63. PMID: 11978393
- A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. | Nishimoto, S., et al. 2003. Eur J Biochem. 270: 2521-31. PMID: 12755708
- Genomic organization, expression, and comparative analysis of noncoding region of the rat Ndrg4 gene. | Maeda, A., et al. 2004. Gene. 324: 149-58. PMID: 14693380
- Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. | Hongo, S., et al. 2006. J Cell Biochem. 98: 185-93. PMID: 16408304
- Smooth muscle-associated protein 8: distribution and biological activity in the rat brain. | Brailoiu, GC., et al. 2007. J Neurosci Res. 85: 1789-96. PMID: 17465030
- Differential expression patterns of NDRG family proteins in the central nervous system. | Okuda, T., et al. 2008. J Histochem Cytochem. 56: 175-82. PMID: 17998568
- Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. | Qu, X., et al. 2008. Dev Biol. 317: 486-96. PMID: 18407257
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDRG4 Antibody (C-8) | sc-514144 | 200 µg/ml | $322.00 | |||
NDRG4 Antibody (C-8): m-IgGλ BP-HRP Bundle | sc-524622 | 200 µg Ab, 40 µg BP | $361.00 | |||
NDRG4 Antibody (C-8): m-IgG2b BP-HRP Bundle | sc-549555 | 200 µg Ab; 10 µg BP | $361.00 | |||
NDRG4 Antibody (C-8) AC | sc-514144 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NDRG4 Antibody (C-8) HRP | sc-514144 HRP | 200 µg/ml | $322.00 | |||
NDRG4 Antibody (C-8) FITC | sc-514144 FITC | 200 µg/ml | $336.00 | |||
NDRG4 Antibody (C-8) PE | sc-514144 PE | 200 µg/ml | $349.00 | |||
NDRG4 Antibody (C-8) Alexa Fluor® 488 | sc-514144 AF488 | 200 µg/ml | $364.00 | |||
NDRG4 Antibody (C-8) Alexa Fluor® 546 | sc-514144 AF546 | 200 µg/ml | $364.00 | |||
NDRG4 Antibody (C-8) Alexa Fluor® 594 | sc-514144 AF594 | 200 µg/ml | $364.00 | |||
NDRG4 Antibody (C-8) Alexa Fluor® 647 | sc-514144 AF647 | 200 µg/ml | $364.00 | |||
NDRG4 Antibody (C-8) Alexa Fluor® 680 | sc-514144 AF680 | 200 µg/ml | $364.00 | |||
NDRG4 Antibody (C-8) Alexa Fluor® 790 | sc-514144 AF790 | 200 µg/ml | $364.00 | |||
NDRG4 (C-8) Neutralizing Peptide | sc-514144 P | 100 µg/0.5 ml | $69.00 |