NDOR1 Inhibitors
NDOR1 Inhibitors, as inferred from the broader roles of NDOR1 and its involvement in ROS production, can shift cellular processes such as cell proliferation, apoptosis, and autophagy, among others. For instance, U0126, a MEK inhibitor, and PD98059, an ERK inhibitor, can dampen the MAPK/ERK pathway, which is known to be activated by ROS. Suppression of this pathway can reduce ROS production and thus indirectly inhibit NDOR1. Similarly, inhibitors of the PI3K/Akt pathway, such as LY294002 and Wortmannin, could indirectly inhibit NDOR1 by reducing its activation, as this pathway is known to activate NADPH oxidases, including NDOR1, for ROS production.
Inhibitors such as SB202190, a selective p38 MAPK inhibitor, and SP600125, a JNK inhibitor, can indirectly inhibit NDOR1 by reducing oxidative stress. These pathways, p38 MAPK and JNK, become activated underoxidative stress conditions, which NDOR1 contributes to by producing ROS. By suppressing these pathways, oxidative stress in the cell is reduced, leading to decreased activation of NDOR1. Additionally, inhibitors like Rapamycin, an mTOR inhibitor, could reduce activation of NDOR1, as mTOR signaling is known to stimulate NADPH oxidases under certain conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that suppresses the PI3K/Akt pathway. The PI3K/Akt pathway is known to activate NADPH oxidases, including NDOR1, for ROS production. Hence, inhibition of this pathway can indirectly inhibit NDOR1 by reducing its activation. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB202190 is a selective p38 MAPK inhibitor. The p38 MAPK pathway becomes activated under oxidative stress conditions, which NDOR1 contributes to by producing ROS. Inhibition of p38 MAPK can therefore reduce oxidative stress, potentially leading to decreased activation of NDOR1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK inhibitor. JNK pathways can be activated by ROS, which NDOR1 contributes to. Hence, inhibiting this pathway can indirectly inhibit NDOR1 by reducing ROS-mediated stimulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an ERK inhibitor that can suppress the MAPK/ERK pathway. This pathway is known to be activated by ROS. By suppressing this pathway, PD98059 can reduce ROS-mediated stimulation of NDOR1, leading to its indirect inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that suppresses the PI3K/Akt pathway. The PI3K/Akt pathway is known to stimulate NADPH oxidases, including NDOR1. Therefore, its suppression can indirectly inhibit NDOR1 by reducing its activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. mTOR signaling is known to stimulate NADPH oxidases under certain conditions. Therefore, inhibiting mTOR could potentially reduce activation of NDOR1. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
Z-VAD-FMK is a caspase inhibitor. As ROS, generated by NDOR1, can trigger caspase activation and apoptosis, the use of this inhibitor can potentially decrease ROS-mediated activation of NDOR1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. Proteasomes are known to be activated by oxidative stress, which NDOR1 contributes to. Hence, inhibiting proteasomes can indirectly inhibit NDOR1 by reducing oxidative stress. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-MA is an autophagy inhibitor. Autophagy can be induced by oxidative stress, which NDOR1 contributes to. Therefore, reducing autophagy can indirectly inhibit NDOR1 by lowering oxidative stress. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is a calcineurin inhibitor. Calcineurin is known to be activated by ROS. Thus, inhibiting calcineurin can indirectly inhibit NDOR1 by reducing ROS-mediated stimulation. | ||||||