NCAG1 Activators

Dermatan sulfate epimerase-like (referred to as DSE-like) protein is conceptually analogous to dermatan sulfate epimerase (DSE), which is an enzyme that plays a crucial role in the post-translational modification of proteoglycans. Proteoglycans are essential components of the extracellular matrix (ECM), which provide structural support to tissues and play a role in cell signaling. While specific details about DSE-like may be limited, its function is inferred from its homology to DSE.Dermatan sulfate (DS) is a type of glycosaminoglycan (GAG) that is found in the ECM and is known to interact with a variety of proteins including growth factors, cytokines, and enzymes. The biosynthesis of DS involves the epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) within the chondroitin sulfate (CS) chain. This epimerization is catalyzed by DSE, which alters the sugar configuration, thereby converting CS to DS. The presence of IdoA residues is critical for the biological functions of DS, including its binding properties and interaction with various proteins.

DSE-like protein is presumed to share similar enzymatic activities with DSE, possibly involved in the epimerization process or other modifications of GAG chains that affect the structure and function of the ECM. These modifications can influence a range of biological processes, such as cell adhesion, migration, and the modulation of signaling pathways that are important for tissue development and repair.The specific roles and mechanisms of DSE-like protein in ECM remodeling, as well as its potential involvement in disease processes such as fibrosis or impaired wound healing, require further investigation.