NARC-1 Activators
The chemical class of NARC-1 activators comprises a diverse range of compounds that intricately modulate NARC-1 activation through specific cellular pathways. A769662, for instance, indirectly activates NARC-1 by enhancing AMPK activity within the AMPK signaling pathway, impacting cellular energy homeostasis. Forskolin stimulates adenylate cyclase, increasing cAMP levels, and indirectly activates NARC-1 within the cAMP signaling pathway. GW501516 activates PPAR-δ, influencing lipid metabolism and cellular energy balance, leading to increased NARC-1 activation within the PPAR-δ signaling pathway. 2-Deoxy-D-glucose inhibits glycolysis, altering cellular energy dynamics and indirectly activating NARC-1 within the glycolysis inhibition pathway. Bay 11-7082 inhibits NF-κB, relieving its negative regulation on NARC-1 and enhancing activation within the NF-κB signaling pathway.
SB431542 disrupts TGF-β signaling by inhibiting ALK5, leading to increased NARC-1 activation within the TGF-β signaling pathway. AICAR, similar to A769662, activates AMPK, impacting cellular energy homeostasis and indirectly activating NARC-1 within the AMPK signaling pathway. Compound C inhibits AMPK, disrupting cellular energy homeostasis and indirectly activating NARC-1 within the AMPK inhibition pathway. Rosiglitazone activates PPAR-γ, influencing lipid metabolism and cellular energy balance, leading to increased NARC-1 activation within the PPAR-γ signaling pathway. 3-Bromopyruvate and sc-514 both influence glycolysis and IKK-2 signaling, respectively, indirectly activating NARC-1 within their respective pathways. Selumetinib inhibits MEK1/2, disrupting MAPK/ERK signaling and leading to increased NARC-1 activation within this pathway. This intricate network of chemical modulators offers a versatile toolkit for researchers to precisely control NARC-1 activation, shedding light on the regulatory mechanisms of this protein and the complexity of cellular signaling networks. The detailed understanding of these interactions can pave the way for further exploration of NARC-1 in various cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662 activates AMP-activated protein kinase (AMPK), indirectly activating NARC-1. By enhancing AMPK activity, A769662 influences cellular energy homeostasis, leading to increased NARC-1 activation within the AMPK signaling pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase, increasing cAMP levels and indirectly activating NARC-1. Elevated cAMP levels modulate cellular processes, leading to enhanced NARC-1 activation within the cAMP signaling pathway. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 activates peroxisome proliferator-activated receptor delta (PPAR-δ), indirectly activating NARC-1. Through PPAR-δ activation, GW501516 influences lipid metabolism and cellular energy balance, leading to increased NARC-1 activation within the PPAR-δ signaling pathway. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 inhibits NF-κB, indirectly activating NARC-1. NF-κB negatively regulates NARC-1, and Bay 11-7082's inhibition relieves this constraint, leading to enhanced NARC-1 activation within the NF-κB signaling pathway. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, indirectly activating NARC-1. Similar to A769662, AICAR enhances AMPK activity, influencing cellular energy homeostasis and leading to increased NARC-1 activation within the AMPK signaling pathway. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
BML-275 inhibits AMPK, indirectly activating NARC-1. By blocking AMPK, BML-275 disrupts cellular energy homeostasis, leading to increased NARC-1 activation within the AMPK inhibition pathway. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone activates PPAR-γ, indirectly activating NARC-1. Through PPAR-γ activation, Rosiglitazone influences lipid metabolism and cellular energy balance, leading to increased NARC-1 activation within the PPAR-γ signaling pathway. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $66.00 $89.00 | 13 | |
SC-514 inhibits IKK-2, indirectly activating NARC-1. IKK-2 negatively regulates NARC-1, and SC-514's inhibition relieves this constraint, leading to enhanced NARC-1 activation within the IKK-2 signaling pathway. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $28.00 $80.00 $412.00 $1860.00 $2962.00 | 5 | |
Selumetinib inhibits MEK1/2, indirectly activating NARC-1. By blocking MEK1/2, Selumetinib disrupts MAPK/ERK signaling, leading to increased NARC-1 activation within this pathway. | ||||||