Myosin IIIa Inhibitors
Myosin IIIa inhibitors comprise a diverse range of compounds that primarily focus on modulating the actomyosin cytoskeleton. These inhibitors do not directly target myosin IIIa but influence its function by altering the biochemical and cellular context in which it operates. For instance, agents like Blebbistatin and BDM, which target myosin II ATPase activity, exert effects on the broader myosin family. Changes in the ATPase activity impact the interaction dynamics between actin and myosin, which can influence myosin IIIa's function in cellular processes.
Moreover, myosin's activity and interactions with actin can be modulated by its phosphorylation state. Compounds like ML-7 and ML-9, which inhibit myosin light chain kinase (MLCK), and others like Y-27632 and H-1152, which target Rho-associated kinase (ROCK), play pivotal roles in this regulation. By altering the phosphorylation dynamics, these inhibitors can change the functional state of myosin IIIa. On the other hand, compounds that specifically modulate actin dynamics, such as SMIFH2, Latrunculin A, and Jasplakinolide, provide an additional layer of control. Altering the actin framework directly impacts myosin IIIa, given that its function is intrinsically tied to its interactions with actin.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibits myosin II ATPase activity, affecting actin-myosin interactions. Myosin IIIa's activity can be indirectly altered due to changes in cytoskeleton dynamics. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibitor of myosin light chain kinase (MLCK). By targeting MLCK, it affects the phosphorylation state of myosin, potentially influencing myosin IIIa functionality. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
Another MLCK inhibitor. By dampening MLCK activity, it can alter the state of myosin phosphorylation and thereby influence myosin IIIa. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits Rho-associated kinase (ROCK) which plays a role in regulating myosin. Myosin IIIa may be influenced due to changes in the myosin phosphorylation state. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibitor of formin proteins which nucleate actin. Affects actin dynamics and can potentially alter the environment and functionality of myosin IIIa. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin polymerization by binding to actin monomers. Changes in actin dynamics can indirectly impact myosin IIIa function. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and affects actin dynamics. By modulating the actin network, it can have implications on myosin IIIa interactions. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Binds actin filaments' barbed ends, preventing polymerization. Alterations in actin dynamics can affect myosin IIIa functionality. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
Another ROCK inhibitor. Affects the myosin phosphorylation state and potentially the activity of myosin IIIa. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Protein phosphatase inhibitor. By altering the phosphorylation landscape, it can indirectly influence myosin IIIa. | ||||||