Date published: 2025-10-15

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MyoD Inhibitors

MyoD inhibitors belong to a specific chemical class that has garnered attention within the realm of molecular research due to their distinctive interactions with cellular processes. These inhibitors are designed to target and modulate the activity of the MyoD protein, which holds a crucial role in the regulation of muscle differentiation. By focusing on the MyoD protein, these inhibitors aim to influence the intricate mechanisms that govern the transition of stem cells into muscle cells, a process known as myogenesis. At the molecular level, MyoD inhibitors operate by interrupting the normal signaling pathways that trigger the activation of MyoD. These inhibitors often possess a distinct chemical structure that allows them to bind to specific regions of the MyoD protein, thereby altering its conformation and preventing its usual binding interactions with other cellular components. This disruption leads to a downstream effect on the transcription of genes involved in muscle development, effectively halting or altering the progression of myogenesis.

Researchers have extensively studied the mechanisms by which MyoD inhibitors impede the functions of MyoD, shedding light on applications for controlling cellular differentiation and tissue regeneration. In summary, MyoD inhibitors represent a noteworthy class of compounds that target the MyoD protein, a key player in muscle differentiation processes. Through intricate molecular interactions, these inhibitors exert their effects on cellular signaling pathways, thereby influencing the regulatory mechanisms that govern myogenesis.

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Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(±)-Blebbistatin

674289-55-5sc-203532B
sc-203532
sc-203532A
sc-203532C
sc-203532D
5 mg
10 mg
25 mg
50 mg
100 mg
$179.00
$307.00
$455.00
$924.00
$1689.00
7
(1)

Binds to myosin and inhibits its ATPase activity, preventing actin-myosin cross-bridge formation.

Omecamtiv Mecarbil

873697-71-3sc-507399
5 mg
$255.00
(0)

Allosteric inhibitor of myosin ATPase activity, reducing the actin-myosin interaction and muscle contraction.

ML-7 hydrochloride

110448-33-4sc-200557
sc-200557A
10 mg
50 mg
$89.00
$262.00
13
(1)

Selectively inhibits myosin light chain kinase (MLCK), leading to reduced phosphorylation of myosin light chains.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

Inhibits Rho-associated protein kinase (ROCK), preventing myosin light chain phosphorylation and smooth muscle contraction.

H-89 dihydrochloride

130964-39-5sc-3537
sc-3537A
1 mg
10 mg
$92.00
$182.00
71
(2)

Inhibits protein kinases, including myosin light chain kinase (MLCK), affecting myosin-mediated cellular processes.

ML-9

105637-50-1sc-200519
sc-200519A
sc-200519B
sc-200519C
10 mg
50 mg
100 mg
250 mg
$110.00
$440.00
$660.00
$1200.00
2
(1)

Inhibits myosin light chain kinase (MLCK), impacting myosin-mediated cellular processes and muscle contraction.

Jasplakinolide

102396-24-7sc-202191
sc-202191A
50 µg
100 µg
$180.00
$299.00
59
(1)

Disrupts actin polymerization, indirectly affecting myosin's interaction with actin filaments in the cell.

Latrunculin A, Latrunculia magnifica

76343-93-6sc-202691
sc-202691B
100 µg
500 µg
$260.00
$799.00
36
(2)

Binds to actin monomers, preventing their polymerization into filaments and consequently interfering with myosin-actin interactions.

CK 666

442633-00-3sc-361151
sc-361151A
10 mg
50 mg
$315.00
$1020.00
5
(0)

Disrupts actin filament assembly by inhibiting the Arp2/3 complex, indirectly affecting myosin-actin interactions.

Wiskostatin

253449-04-6sc-204399
sc-204399A
sc-204399B
sc-204399C
1 mg
5 mg
25 mg
50 mg
$48.00
$122.00
$432.00
$812.00
4
(1)

Inhibits the activity of the Wiskott-Aldrich syndrome protein (WASP) family, affecting actin dynamics and myosin-mediated processes.