MyoD inhibitors belong to a specific chemical class that has garnered attention within the realm of molecular research due to their distinctive interactions with cellular processes. These inhibitors are designed to target and modulate the activity of the MyoD protein, which holds a crucial role in the regulation of muscle differentiation. By focusing on the MyoD protein, these inhibitors aim to influence the intricate mechanisms that govern the transition of stem cells into muscle cells, a process known as myogenesis. At the molecular level, MyoD inhibitors operate by interrupting the normal signaling pathways that trigger the activation of MyoD. These inhibitors often possess a distinct chemical structure that allows them to bind to specific regions of the MyoD protein, thereby altering its conformation and preventing its usual binding interactions with other cellular components. This disruption leads to a downstream effect on the transcription of genes involved in muscle development, effectively halting or altering the progression of myogenesis.
Researchers have extensively studied the mechanisms by which MyoD inhibitors impede the functions of MyoD, shedding light on applications for controlling cellular differentiation and tissue regeneration. In summary, MyoD inhibitors represent a noteworthy class of compounds that target the MyoD protein, a key player in muscle differentiation processes. Through intricate molecular interactions, these inhibitors exert their effects on cellular signaling pathways, thereby influencing the regulatory mechanisms that govern myogenesis.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Binds to myosin and inhibits its ATPase activity, preventing actin-myosin cross-bridge formation. | ||||||
Omecamtiv Mecarbil | 873697-71-3 | sc-507399 | 5 mg | $255.00 | ||
Allosteric inhibitor of myosin ATPase activity, reducing the actin-myosin interaction and muscle contraction. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Selectively inhibits myosin light chain kinase (MLCK), leading to reduced phosphorylation of myosin light chains. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits Rho-associated protein kinase (ROCK), preventing myosin light chain phosphorylation and smooth muscle contraction. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
Inhibits protein kinases, including myosin light chain kinase (MLCK), affecting myosin-mediated cellular processes. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
Inhibits myosin light chain kinase (MLCK), impacting myosin-mediated cellular processes and muscle contraction. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Disrupts actin polymerization, indirectly affecting myosin's interaction with actin filaments in the cell. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin monomers, preventing their polymerization into filaments and consequently interfering with myosin-actin interactions. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
Disrupts actin filament assembly by inhibiting the Arp2/3 complex, indirectly affecting myosin-actin interactions. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Inhibits the activity of the Wiskott-Aldrich syndrome protein (WASP) family, affecting actin dynamics and myosin-mediated processes. |