Myo-inositol monophosphatase 1 Inhibitors
Myo-inositol monophosphatase 1 (IMPase 1) inhibitors are a class of chemical compounds that target the enzymatic activity of Myo-inositol monophosphatase 1, an enzyme that plays a pivotal role in the phosphatidylinositol signaling pathway. IMPase 1 is primarily responsible for dephosphorylating inositol monophosphate to produce free myo-inositol, a critical component in the biosynthesis of phosphatidylinositol and its derivatives. These compounds bind to the active site of IMPase 1, blocking its catalytic activity and thus interrupting the recycling of inositol phosphates back into free myo-inositol. By inhibiting this enzyme, the phosphoinositide signaling pathway, which is involved in various cellular processes like signal transduction, membrane trafficking, and cell growth, is modulated.
Structurally, IMPase 1 inhibitors are often characterized by their ability to chelate the divalent metal ions, typically magnesium (Mg²⁺), that are crucial cofactors for the enzymatic activity of IMPase 1. This chelation disrupts the necessary metal ion coordination within the enzyme's active site, leading to a loss of function. In addition to their ability to bind metal ions, many IMPase 1 inhibitors exhibit specific interactions with amino acid residues within the enzyme's active site, which enhances their binding affinity and selectivity. The study of these inhibitors extends into understanding their structure-activity relationships, exploring variations in chemical scaffolds to optimize their inhibitory potency and stability. Researchers in biochemistry and molecular biology are particularly interested in these inhibitors for their utility in probing the mechanistic details of inositol phosphate metabolism and their role in broader cellular functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium carbonate can directly compete with magnesium, an essential cofactor for IMPase 1, leading to a decrease in enzyme activity. This competitive inhibition may downregulate IMPase 1 expression by interfering with the enzyme's normal function in inositol phosphate cycling. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine may deplete inositol pools by inhibiting IMPase 1. This depletion could create a feedback loop that downregulates the transcription of the IMPase 1 gene as the cell attempts to conserve its resources. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid could directly inhibit the expression of IMPase 1 by interfering with transcription factors or promoters that are responsible for the enzyme's gene expression, leading to reduced production of the enzyme. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $318.00 | 9 | |
Fluoxetine may indirectly reduce the expression of IMPase 1 by altering the concentration of neurotransmitters, which may disrupt the myo-inositol signaling pathway and result in decreased synthesis of the enzyme. | ||||||
scyllo-Inositol | 488-59-5 | sc-202808 sc-202808A | 5 mg 25 mg | $72.00 $220.00 | ||
Scyllo-inositol, as a structural analog of the substrate of IMPase 1, could competitively inhibit the enzyme's activity. This inhibition might trigger a feedback loop that downregulates the expression of the protein. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate has the potential to inhibit the enzymatic activity of IMPase 1 by altering its metal binding site, potentially leading to a reduced expression of the enzyme due to lower functional demand. | ||||||
Phytic acid solution | 83-86-3 | sc-205806 sc-205806A | 100 ml 500 ml | $151.00 $515.00 | ||
Phytic acid, a polyphosphorylated carbohydrate, can sequester magnesium ions, reducing the availability of this cofactor for IMPase 1 activity and thus potentially leading to a decrease in its expression. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium fluoride can act as an inhibitor of various enzymes, including phosphatases. Its presence could decrease IMPase 1 activity, prompting a reduction in the enzyme's expression due to diminished functional output. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, by blocking calcium influx, can disrupt calcium-mediated intracellular signaling. This disruption could extend to the calcium-dependent regulation of IMPase 1 expression, leading to decreased levels of the enzyme. | ||||||