Myo-inositol monophosphatase 1 Activators
Myo-inositol monophosphatase 1 (IMPA1) is an enzyme of significant biological interest due to its pivotal role in the phosphatidylinositol signaling pathway. This enzyme is responsible for the hydrolysis of inositol monophosphate to free myo-inositol, a precursor in the synthesis of phosphatidylinositol and phosphoinositides. These molecules are critical components of the cell membrane and are involved in a variety of cellular processes including cell growth, survival, and communication. The regulation of IMPA1 is thus crucial for maintaining cellular homeostasis and facilitating the proper transmission of cellular signals. As a result, the expression levels of IMPA1 are tightly controlled, and understanding the factors that can induce its expression is an area of intense research.
Various chemical compounds have been identified that can potentially induce the expression of IMPA1. These activators can initiate a range of cellular mechanisms that result in increased transcription of the IMPA1 gene. For instance, lithium compounds such as Lithium Chloride and Lithium Sulfate, are known to interact with the enzyme, leading to indirect upregulation of its expression as cells work to rebalance inositol phosphate levels. Anticonvulsants like Sodium Valproate and Carbamazepine may upregulate IMPA1 by altering chromatin structure or modifying transcription factor activity. Similarly, compounds that interact with neurotransmitter systems, such as the antipsychotics Haloperidol and Chlorpromazine, or the antidepressant Fluoxetine, could also lead to an upsurge in the enzyme's expression. This could be part of a broader adaptative response to changes in synaptic activity. Moreover, molecules like Resveratrol and Curcumin, known for their broad biological activities, might stimulate IMPA1 expression through their interactions with cellular signaling pathways and transcription factors. These compounds, among others, are of scientific interest for their ability to induce the expression of IMPA1, shedding light on the intricate regulation of this enzyme and its role in cellular physiology.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Chronic exposure to lithium chloride can lead to a compensatory upsurge in IMPA1 expression, as the enzyme's inhibition by lithium necessitates a homeostatic response for cellular balance. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid sodium salt may escalate the expression of IMPA1 by interacting with histone deacetylases, possibly leading to a more open chromatin structure around the IMPA1 gene for transcription. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine may prompt the expression of IMPA1 by altering the activity of transcription factors involved in neuroprotective responses, potentially as a defensive cellular mechanism. | ||||||
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Haloperidol may provoke an increase in IMPA1 expression as part of the neuroadaptive process, given its role in modulating neurotransmitter systems that are linked to enzyme activity. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine could stimulate the transcription of IMPA1 by disrupting dopaminergic and other neurotransmitter pathways, which might trigger a homeostatic increase in enzyme expression. | ||||||
Olanzapine | 132539-06-1 | sc-212469 | 100 mg | $133.00 | 6 | |
Olanzapine might catalyze the upregulation of IMPA1 expression due to its antagonistic effects on various neurotransmitter receptors, thereby instigating changes in intracellular signaling. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $318.00 | 9 | |
Fluoxetine could initiate an upsurge in IMPA1 expression by increasing the synaptic levels of serotonin, which may lead to downstream changes in gene transcription processes. | ||||||
Lamotrigine | 84057-84-1 | sc-201079 sc-201079A | 10 mg 50 mg | $120.00 $486.00 | 1 | |
Lamotrigine may trigger an upregulation of IMPA1 expression through its dampening effect on voltage-sensitive sodium channels, which could alter neuronal excitability and gene expression. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil has the potential to stimulate an upturn in IMPA1 expression by blocking calcium channels, which could lead to alterations in calcium-mediated signaling pathways and gene transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may propel an increase in IMPA1 expression through its action as an antioxidant, which could initiate a cascade of cellular responses culminating in the transcription of protective genes. | ||||||