MYBBP1A Inhibitors
MYBBP1A inhibitors represent a class of chemicals designed to modulate the activity of MYBBP1A, a protein involved in various cellular processes, including transcriptional regulation and interaction with p53. While direct inhibitors targeting MYBBP1A specifically are limited, several compounds indirectly influence MYBBP1A by targeting key pathways associated with its regulation. Pifithrin-α inhibits p53-mediated apoptosis and transcriptional activity, potentially influencing MYBBP1A due to its interaction with p53. C646 and Nutlin-3 impact MYBBP1A indirectly by affecting p300, a histone acetyltransferase that interacts with MYBBP1A. Tenovin-6 and Sirtinol modulate MYBBP1A by influencing SIRT1 and SIRT2, leading to alterations in MYBBP1A's acetylation status. MG-132, a proteasome inhibitor, affects the degradation of proteins, including MYBBP1A, potentially impacting its cellular levels and functions.
BML-281 inhibits the interaction between MYBBP1A and p53, while EX-527 (Selisistat) specifically targets SIRT1, influencing the deacetylation of MYBBP1A. Anacardic Acid, CAY10602, Cambinol, and SRT1720 collectively impact MYBBP1A through their effects on histone acetyltransferases (p300, PCAF) and deacetylases (SIRT1, SIRT2). In summary, MYBBP1A inhibitors represent a diverse array of compounds that modulate MYBBP1A either directly or indirectly through interactions with key regulatory proteins and enzymes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pifithrin-α hydrobromide | 63208-82-2 | sc-45050 sc-45050A | 5 mg 25 mg | $120.00 $300.00 | 36 | |
Inhibits p53-mediated apoptosis and transcriptional activity, potentially influencing MYBBP1A indirectly as MYBBP1A interacts with p53. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
Inhibits p300, a histone acetyltransferase that interacts with MYBBP1A, modulating its acetylation status and potentially affecting its regulatory functions. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Activates SIRT1 and SIRT2, leading to deacetylation of MYBBP1A, thereby potentially influencing its regulatory functions. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
Inhibits SIRT1 and SIRT2, potentially modulating the acetylation status of MYBBP1A and affecting its regulatory functions. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Inhibits the proteasome, influencing the degradation of proteins, including MYBBP1A, and potentially impacting its cellular levels and functions. | ||||||
(+)-Nutlin-3 | 675576-97-3 | sc-222085 sc-222085A | 500 µg 1 mg | $94.00 $122.00 | ||
Inhibits the interaction between p53 and MDM2, potentially impacting MYBBP1A indirectly as MYBBP1A interacts with p53. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $87.00 | 32 | |
Selective SIRT1 inhibitor, affecting the deacetylation of MYBBP1A and potentially modulating its regulatory functions. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Inhibits the histone acetyltransferase activity of p300, potentially impacting the acetylation status of MYBBP1A and its regulatory functions. | ||||||
SIRT1/2 Inhibitor IV, Cambinol | 14513-15-6 | sc-204280 | 5 mg | $145.00 | 4 | |
Inhibits SIRT1 and SIRT2, affecting the deacetylation of MYBBP1A, potentially modulating its regulatory functions. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
Activates SIRT1, leading to the deacetylation of MYBBP1A and potentially influencing its regulatory functions. | ||||||