MVD Activators
MVD activators are compounds that influence the activity of diphosphomevalonate decarboxylase indirectly by modulating the mevalonate pathway. This pathway is critical for the synthesis of sterols, including cholesterol and non-sterol isoprenoids, which are vital for numerous cellular functions. The activators include substrates, intermediate compounds, and feedback modulators that can elevate the functional demand for MVD1's enzymatic action. Some of these compounds, such as geranylgeraniol and farnesol, are natural intermediates in the biosynthesis of isoprenoids and sterols. They can augment the pool of precursors for downstream enzymes, leading to a compensatory increase in MVD1 activity.
Additionally, the modulation of the mevalonate pathway through increased demand for end products or by altering the expression levels of pathway enzymes also serves as a mechanism for the indirect activation of MVD1. These mechanisms of action are supported by a fundamental principle of biochemistry, where the accumulation of substrates or the enhancement of downstream metabolic demand can lead to an increase in enzyme activity through substrate availability and feedback regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geranylgeraniol | 24034-73-9 | sc-200858 sc-200858A | 20 mg 100 mg | $159.00 $465.00 | 14 | |
A substrate for the enzyme geranylgeranyl diphosphate synthase, which provides precursors downstream of MVD1. Increasing the concentration of this compound can increase flux through the mevalonate pathway, thereby potentially increasing MVD1 activity due to elevated substrate demand. | ||||||
Farnesol | 4602-84-0 | sc-204748 sc-204748A | 50 ml 100 ml | $275.00 $367.00 | 2 | |
As a precursor to squalene, this compound can enhance the pool of substrates in the cholesterol biosynthesis pathway, which may indirectly stimulate MVD1 activity by increasing pathway flux. | ||||||
Squalene | 111-02-4 | sc-281155 sc-281155A sc-281155B | 10 ml 100 ml 500 ml | $48.00 $90.00 $211.00 | 1 | |
By increasing the levels of squalene, this molecule can create a demand for more upstream products, possibly leading to increased activity of MVD1 to meet this demand. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
As a cofactor for many enzymes, adequate zinc levels are crucial for the proper function of enzymatic reactions, including those in the mevalonate pathway. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium acts as a cofactor for various enzymes, and its presence is essential for ATP-utilizing enzymes in the mevalonate pathway. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
By being a product of the mevalonate pathway, high levels of Coenzyme Q10 might stimulate the pathway's activity to replenish its levels. | ||||||