MVD Antibody (H-11): sc-376975
- MVD Antibody (H-11) is a mouse monoclonal IgG1 κ MVD antibody, cited in 10 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 165-203 within an internal region of MVD of human origin
- MVD Antibody (H-11) is recommended for detection of MVD of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MVD Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MVD Antibody (H-11) for WB applications. These reagents are now offered in bundles with MVD Antibody (H-11) (see ordering information below).
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SEE ALSO...
MVD Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects MVD protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MVD antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MVD protein, also known as mevalonate (diphospho) decarboxylase or mevalonate pyrophosphate decarboxylase, is a 400 amino acid enzyme that plays a pivotal role in isoprenoid biosynthesis, which is essential for various cellular functions, including membrane integrity and signaling. Located primarily in the cytoplasm of cells in tissues such as lung, liver, heart, skeletal muscle, brain, pancreas, placenta, and kidney, MVD catalyzes the ATP-dependent conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate, a key precursor in cholesterol synthesis. This enzyme functions as a homodimer, effectively dehydrating and decarboxylating its substrate while hydrolyzing ATP, making MVD a critical component in the early stages of cholesterol biosynthesis. Given MVD′s essential role in cholesterol metabolism, this protein may serve as a valuable target for therapeutic interventions aimed at managing hypercholesterolemia and related cardiovascular diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MVD Antibody (H-11) References:
- Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. | Wadhwa, R., et al. 2003. Biochem Biophys Res Commun. 302: 735-42. PMID: 12646231
- Subcellular distribution of mouse mevalonate pyrophosphate decarboxylase. | Michihara, A., et al. 2003. Biol Pharm Bull. 26: 579-84. PMID: 12736493
- Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice. | Flock, G., et al. 2007. Diabetes. 56: 3006-13. PMID: 17717280
- Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase. | Toth, MJ. and Huwyler, L. 1996. J Biol Chem. 271: 7895-8. PMID: 8626466
- Regulation of fatty acid biosynthesis by intermediates of the cholesterol biosynthetic pathway. | Ku, EC. 1996. Biochem Biophys Res Commun. 225: 173-9. PMID: 8769113
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MVD Antibody (H-11) | sc-376975 | 200 µg/ml | $316.00 | |||
MVD Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-527564 | 200 µg Ab; 10 µg BP | $354.00 | |||
MVD Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-532937 | 200 µg Ab; 20 µg BP | $354.00 | |||
MVD Antibody (H-11) AC | sc-376975 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MVD Antibody (H-11) HRP | sc-376975 HRP | 200 µg/ml | $316.00 | |||
MVD Antibody (H-11) FITC | sc-376975 FITC | 200 µg/ml | $330.00 | |||
MVD Antibody (H-11) PE | sc-376975 PE | 200 µg/ml | $343.00 | |||
MVD Antibody (H-11) Alexa Fluor® 488 | sc-376975 AF488 | 200 µg/ml | $357.00 | |||
MVD Antibody (H-11) Alexa Fluor® 546 | sc-376975 AF546 | 200 µg/ml | $357.00 | |||
MVD Antibody (H-11) Alexa Fluor® 594 | sc-376975 AF594 | 200 µg/ml | $357.00 | |||
MVD Antibody (H-11) Alexa Fluor® 647 | sc-376975 AF647 | 200 µg/ml | $357.00 | |||
MVD Antibody (H-11) Alexa Fluor® 680 | sc-376975 AF680 | 200 µg/ml | $357.00 | |||
MVD Antibody (H-11) Alexa Fluor® 790 | sc-376975 AF790 | 200 µg/ml | $357.00 | |||
MVD (H-11) Neutralizing Peptide | sc-376975 P | 100 µg/0.5 ml | $68.00 |