MVB12A Activators
The ESCRT complexes, including ESCRT-I where MVB12A is involved, play a critical role in the formation of multivesicular bodies (MVBs) and in the sorting of ubiquitinated cargo proteins into these MVBs. They are also crucial in membrane remodeling processes like cytokinesis and the repair of plasma membrane. The activity and stability of the ESCRT-I complex, and thereby MVB12A, are closely linked to the dynamics of endosomal membranes and the presence of specific phosphoinositides like PI3P.
Chemicals like PI3P, YM201636, and Apilimod influence the levels of PI3P and other phosphoinositides, directly impacting the recruitment and assembly of ESCRT complexes on endosomal membranes. Inhibitors of VPS34, such as VPS34-IN1 and SAR405, can affect the production of PI3P, thereby influencing ESCRT function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
YM201636 | 371942-69-7 | sc-204193 | 5 mg | $217.00 | 6 | |
Inhibits PIKfyve, affecting PI3P levels and potentially impacting ESCRT complex function. | ||||||
Apilimod | 541550-19-0 | sc-480051 sc-480051A | 100 mg 1 g | $428.00 $2652.00 | 5 | |
Targets PIKfyve, altering endosomal sorting and possibly affecting ESCRT complexes. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
A specific inhibitor of VPS34, could impact the function of ESCRT complexes. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Inhibits ubiquitin-specific peptidases, affecting protein degradation pathways involving ESCRT. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Inhibits autophagy by targeting VPS34, potentially affecting ESCRT complex function. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
mTOR inhibitor, can affect endosomal trafficking, potentially influencing ESCRT-I complex activities. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
PI3K inhibitor, could indirectly affect the recruitment and function of ESCRT complexes. | ||||||