MSH2_Msh2 Inhibitors
The term MSH2_Msh2 inhibitors refers to a class of chemical compounds that are designed to specifically target and inhibit the activity of the MSH2 protein, often in the context of molecular research and investigations related to DNA repair mechanisms and cellular processes. MSH2, which stands for MutS homolog 2, is a critical component of the DNA mismatch repair (MMR) system in eukaryotic cells, primarily in humans. The MSH2 protein plays an essential role in maintaining genomic stability by recognizing and repairing errors that occur during DNA replication and recombination. These errors, known as DNA mismatches, can lead to mutations if left uncorrected, making MSH2 a key guardian of genetic integrity.
MSH2_Msh2 inhibitors are designed to interfere with the normal functioning of MSH2 by binding to it and disrupting its activity. This inhibition can serve as a valuable tool in the laboratory setting for researchers studying DNA repair processes, as it allows for the controlled manipulation of MMR pathways. By inhibiting MSH2, scientists can gain insights into the fundamental mechanisms of DNA repair, DNA damage response, and genome stability maintenance. These inhibitors are invaluable in elucidating the intricate details of cellular processes related to DNA repair and mutation prevention, ultimately contributing to a deeper understanding of the molecular basis of diseases associated with DNA repair deficiencies and genomic instability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanine | 73-40-5 | sc-211573 | 25 g | $21.00 | ||
Guanine is a naturally occurring nucleobase that competes with mismatched DNA for binding to MSH2, disrupting the recognition of DNA lesions and inhibiting the repair process. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
6-Thioguanine is an antimetabolite that gets incorporated into DNA and disrupts DNA replication. It can also impair MSH2-dependent DNA mismatch repair, leading to genomic instability. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C forms cross-links with DNA, preventing DNA strand separation during repair. This inhibits MSH2's ability to recognize and repair DNA mismatches, resulting in DNA damage accumulation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts that distort the DNA helix. This structural distortion interferes with MSH2's recognition of DNA mismatches, impeding the repair of DNA lesions. | ||||||
Psoralen | 66-97-7 | sc-205965 sc-205965A | 25 mg 100 mg | $103.00 $321.00 | 1 | |
Psoralen intercalates into DNA and forms covalent bonds upon exposure to UV light, leading to DNA cross-linking. This hinders MSH2's ability to recognize and repair DNA mismatches. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, depleting cellular pools of reduced folates required for DNA synthesis and repair. This indirectly impairs MSH2-dependent DNA mismatch repair. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine is a nucleoside analog that gets incorporated into DNA during replication, leading to chain termination and inhibition of MSH2-mediated DNA mismatch repair. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Oxaliplatin forms DNA adducts that interfere with DNA replication and transcription. This disrupts DNA repair processes, including MSH2-dependent mismatch repair, leading to DNA damage. | ||||||
Topotecan | 123948-87-8 | sc-338718 | 100 mg | $582.00 | ||
Topotecan inhibits DNA topoisomerase I, causing DNA strand breaks and preventing the proper recognition and repair of DNA mismatches by MSH2. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and disrupts DNA synthesis. This indirectly affects MSH2's ability to repair DNA mismatches during replication. | ||||||