MrgA2a Activators
MrgA2a Activators encompass a variety of chemical compounds that potentially enhance the functional activity of MrgA2a, a member of the MAS-related GPCR family, predominantly involved in sensory perception and pain modulation. Compounds such as β-Alanine and Capsaicin are known to be agonists for MAS-related receptors and may activate MrgA2a, triggering downstream signaling pathways integral to pain sensation and inflammatory processes. Similarly, agents like Icilin, a synthetic supercooling compound, and Adrenomedullin, a peptide with diverse physiological roles, could enhance MrgA2a activity by inducing receptor activation and modulating pain-related signaling pathways. Additionally, metabolic byproducts such as Lactate may indirectly influence MrgA2a by affecting cellular metabolism and energy status, thereby modulating GPCR signaling pathways.
Moreover, MrgA2a activity is potentially influenced by a range of biologically active substances, including neurotransmitters and inflammatory mediators. Prostaglandin E2 (PGE2) and Bradykinin, both involved in inflammatory processes and pain perception, might interact with MrgA2a to modulate pain and inflammatory signaling through GPCR-mediated pathways. Neurotransmitters such as Serotonin and Histamine, known for their roles in neurotransmission and allergic responses, could enhance MrgA2a activity by influencing sensory perception and pain modulation. Additionally, CGRP (Calcitonin Gene-Related Peptide), a neuropeptide, may interact with MrgA2a, further modulating signaling pathways involved in pain perception and vascular responses. Collectively, these MrgA2a Activators, through their interactions with the receptor, facilitate the modulation of sensory perception and pain signaling pathways, highlighting the diverse mechanisms through which MrgA2a mediates its physiological effects.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, a known agonist for some MAS-related receptors, could potentially enhance MrgA2a activity. Its binding may activate MrgA2a, triggering intracellular signaling pathways related to pain sensation and inflammatory processes. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO, often used as a solvent, can also interact with certain GPCRs. It may modulate MrgA2a activity indirectly by altering membrane fluidity, thereby influencing receptor conformation and signaling. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine, known for its effects on lysosomal function, may also interact with GPCRs. It could potentially enhance MrgA2a activity by affecting intracellular signaling pathways and cellular stress responses that converge on GPCR-mediated signaling. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $91.00 $257.00 | 9 | |
Icilin, a synthetic supercooling agent, has been shown to activate certain MAS-related GPCRs. It may enhance MrgA2a activity by inducing receptor activation and influencing signaling pathways involved in sensory perception. | ||||||
Lactic acid | 50-21-5 | sc-215227 sc-215227A | 100 ml 500 ml | $102.00 $179.00 | 1 | |
Lactate, as a metabolic byproduct, can influence certain GPCR activities. It may indirectly enhance MrgA2a activity by affecting cellular metabolism and energy status, which can modulate GPCR signaling pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2, an inflammatory mediator, might influence MrgA2a activity. Its interaction with MrgA2a could modulate pain perception and inflammatory responses through GPCR-mediated signaling pathways. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin, a peptide involved in pain and inflammation, could potentially enhance MrgA2a activity. It may activate the receptor and influence signaling pathways related to pain sensation and inflammatory responses. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Serotonin, a neurotransmitter, might interact with MrgA2a. Its binding to MrgA2a could enhance receptor activity, influencing signaling pathways related to sensory perception and pain modulation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, involved in allergic responses and neurotransmission, could potentially enhance MrgA2a activity by interacting with the receptor, influencing pathways related to pain and sensory processing. | ||||||