MORN2 Inhibitors
Chemical inhibitors of MORN2 play a role in modulating the protein's involvement in membrane dynamics and endocytosis. Staurosporine, as a broad kinase inhibitor, can inhibit the protein kinases responsible for phosphorylating proteins that MORN2 interacts with, thereby disrupting MORN2's function. Wortmannin and LY294002, both inhibitors of phosphoinositide 3-kinases (PI3K), can disrupt PI3K-dependent pathways that are crucial for the membrane trafficking and curvature processes involving MORN2, leading to its functional inhibition. Another compound, Dynasore, targets dynamin, a GTPase crucial for endocytosis, which is a process MORN2 is known to be involved in. By inhibiting dynamin's activity, Dynasore interferes with vesicle scission, an essential step in endocytosis where MORN2 functions, thereby inhibiting its activity. Similarly, MiTMAB inhibits dynamin's GTPase activity, further disrupting vesicle formation and release, crucial steps in MORN2's functional role.
On the other hand, PAO (phenylarsine oxide) inhibits tyrosine phosphatases, which are also implicated in the endocytic process. This inhibition can hinder the cellular mechanisms that MORN2 relies on, leading to its functional inhibition. Cytochalasin D and Latrunculin A both disrupt actin polymerization, a cytoskeletal process that MORN2 is associated with, particularly regarding membrane curvature. By preventing actin fiber formation, these chemicals can impair MORN2's associated cellular functions. Endosidin2, by disrupting endosomal trafficking, can inhibit MORN2's role in this specific pathway. Brefeldin A's inhibition of protein transport from the ER to the Golgi can disrupt the proper localization and function of MORN2 within the cell. Pitstop 2, targeting clathrin-mediated endocytosis, can inhibit the formation of clathrin-coated vesicles, thereby disrupting MORN2-involved pathways. Finally, Tyrphostin AG 879 inhibits tyrosine kinases, which can lead to the inhibition of MORN2 by interfering with the protein's related endocytic processes, which rely on tyrosine phosphorylation events for functional regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent kinase inhibitor known to inhibit protein kinases. MORN2 is associated with membrane curvature and endocytosis, processes often regulated by kinase activity. Staurosporine can inhibit the kinases that phosphorylate proteins involved in these processes, including MORN2, thereby inhibiting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K). MORN2 is implicated in membrane dynamics modulated by PI3K activity. By inhibiting PI3K, wortmannin can disrupt membrane trafficking and curvature, thereby functionally inhibiting MORN2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, which would inhibit the PI3K-dependent pathways, potentially disrupting membrane dynamics and processes in which MORN2 is involved, leading to functional inhibition. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin, a GTPase involved in endocytosis, a process where MORN2 is implicated. By inhibiting dynamin, Dynasore can disrupt endocytic vesicle scission where MORN2 functions, resulting in inhibition of MORN2. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine oxide (PAO) inhibits tyrosine phosphatases, which are involved in endocytosis. By inhibiting these phosphatases, PAO can disrupt processes that require MORN2, leading to its functional inhibition. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin polymerization. MORN2 is involved in membrane curvature that relies on the cytoskeleton, such as actin. Disruption of actin dynamics can therefore inhibit the function of MORN2 in these processes. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization. Given that MORN2 is associated with actin-dependent processes, inhibiting actin polymerization with latrunculin A would disrupt MORN2's functional role in these processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus. MORN2's function related to membrane trafficking can be inhibited by disrupting this protein transport pathway. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin-mediated endocytosis. By inhibiting clathrin, Pitstop 2 can disrupt endocytic vesicle formation, a process in which MORN2 is functionally involved, leading to its inhibition. | ||||||
Tyrphostin AG 879 | 148741-30-4 | sc-3557 sc-3557A | 5 mg 25 mg | $83.00 $328.00 | 4 | |
Tyrphostin AG 879 inhibits tyrosine kinases. Since MORN2's function is closely related to processes regulated by tyrosine phosphorylation, such as endocytosis, inhibiting these kinases can lead to functional inhibition of MORN2. | ||||||