Date published: 2025-12-10

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Monoamine Oxidase Inhibitors

Santa Cruz Biotechnology now offers a broad range of monoamine oxidase inhibitors for use in various applications. Monoamine oxidase inhibitors (MAOIs) are a class of compounds that inhibit the activity of monoamine oxidase enzymes, which are responsible for the breakdown of monoamines such as serotonin, dopamine, and norepinephrine. These inhibitors are essential tools in scientific research for studying the regulation of neurotransmitter levels and the impact of monoamine metabolism on various biological processes. Researchers utilize MAOIs to investigate the role of monoamines in mood regulation, behavior, and neurophysiology. They are also used to explore the mechanisms underlying neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, as well as psychiatric disorders. By inhibiting monoamine oxidase, scientists can better understand how neurotransmitter dynamics influence neural function and how dysregulation of these systems can lead to disease. MAOIs are also valuable in the development of experimental models for studying the effects of altered monoamine levels in the brain. By offering a comprehensive selection of high-quality monoamine oxidase inhibitors, Santa Cruz Biotechnology supports cutting-edge research in neuroscience and biochemistry. View detailed information on our available monoamine oxidase inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Benserazide·HCl (Ro 4-4602)

14919-77-8sc-200723
sc-200723A
100 mg
1 g
$26.00
$85.00
(1)

Benserazide·HCl, a potent inhibitor of monoamine oxidase, showcases intriguing molecular interactions that modulate neurotransmitter levels. Its unique binding affinity alters enzyme kinetics, effectively slowing the degradation of monoamines. The compound's structural conformation allows for specific interactions with active sites, influencing reaction pathways. Additionally, its solubility characteristics enhance its reactivity in various biochemical environments, contributing to its distinct behavior in enzymatic processes.

Phenelzine sulfate salt

156-51-4sc-215701
5 g
$310.00
3
(1)

Phenelzine sulfate salt acts as a selective monoamine oxidase inhibitor, exhibiting unique interactions with the enzyme's active site. Its structural features facilitate the formation of stable enzyme-inhibitor complexes, significantly impacting the catalytic efficiency of monoamine degradation. The compound's ability to alter electron distribution enhances its reactivity, while its solubility profile allows for effective diffusion in biological systems, influencing metabolic pathways and reaction dynamics.

R(−)-Deprenyl hydrochloride

14611-52-0sc-200742
sc-200742A
sc-200742B
100 mg
250 mg
1 g
$32.00
$77.00
$281.00
(1)

R(-)-Deprenyl hydrochloride functions as a selective monoamine oxidase inhibitor, characterized by its unique binding affinity to the enzyme's flavin cofactor. This interaction stabilizes the enzyme's conformation, leading to altered reaction kinetics and reduced substrate turnover. The compound's stereochemistry contributes to its specificity, while its lipophilic nature enhances membrane permeability, facilitating its engagement in neurochemical pathways and modulating neurotransmitter levels.

Clorgyline hydrochloride

17780-75-5sc-214749
sc-214749A
50 mg
100 mg
$125.00
$210.00
2
(1)

Clorgyline hydrochloride acts as a selective monoamine oxidase inhibitor, exhibiting a strong affinity for the enzyme's active site. Its unique structural features allow for specific interactions with the enzyme's flavin adenine dinucleotide (FAD) cofactor, effectively hindering the oxidative deamination of neurotransmitters. This inhibition alters metabolic pathways, resulting in a distinctive modulation of monoamine levels, while its hydrophobic characteristics promote effective cellular uptake and distribution.

S(-)-Carbidopa

38821-49-7sc-361978
5 g
$500.00
(0)

S(-)-Carbidopa functions as a monoamine oxidase inhibitor by selectively binding to the enzyme's active site, disrupting its catalytic activity. Its stereochemistry enhances interactions with the enzyme's binding pocket, leading to altered reaction kinetics and a reduction in the breakdown of key neurotransmitters. This compound's unique conformation facilitates specific molecular interactions, influencing metabolic pathways and contributing to its distinct biochemical profile.

Ro 16-6491

94319-79-6sc-200743
sc-200743A
200 mg
1 g
$57.00
$218.00
(0)

Ro 16-6491 acts as a monoamine oxidase inhibitor through its ability to form stable complexes with the enzyme, effectively hindering its function. The compound's unique structural features allow for selective interactions with the enzyme's active site, modulating the kinetics of neurotransmitter degradation. This selective binding alters the enzyme's conformational dynamics, impacting various metabolic pathways and enhancing the stability of certain biogenic amines within the system.

Rasagiline

136236-51-6sc-204875
sc-204875A
25 mg
100 mg
$101.00
$210.00
(1)

Rasagiline functions as a monoamine oxidase inhibitor by engaging in specific non-covalent interactions with the enzyme, leading to a reduction in its catalytic activity. Its unique molecular architecture facilitates preferential binding to the enzyme's active site, influencing the reaction kinetics of neurotransmitter metabolism. This interaction not only stabilizes the enzyme's conformation but also affects the turnover rates of various substrates, thereby modulating biochemical pathways associated with amine regulation.

Pimprinine

13640-26-1sc-202288
1 mg
$291.00
(0)

Pimprinine acts as a monoamine oxidase by selectively interacting with the enzyme's active site, altering its conformational dynamics. This compound exhibits unique binding affinities that influence the enzyme's substrate specificity and catalytic efficiency. Its structural features promote distinct electron transfer mechanisms, impacting the degradation pathways of biogenic amines. Additionally, Pimprinine's presence can modulate the redox state of the enzyme, further affecting neurotransmitter homeostasis.

2-Propynal

624-67-9sc-344980
1 g
$400.00
(0)

2-Propynal functions as a monoamine oxidase by engaging in specific interactions with the enzyme's active site, leading to alterations in its catalytic behavior. Its unique carbonyl group facilitates the formation of transient intermediates, enhancing reaction kinetics. The compound's steric properties influence substrate accessibility, while its electron-withdrawing characteristics can stabilize charged transition states, ultimately affecting the metabolic pathways of amines.

Ethyl homovanillate

60563-13-5sc-235050
1 g
$54.00
(0)

Ethyl homovanillate acts as a monoamine oxidase by selectively binding to the enzyme's active site, promoting conformational changes that modulate its activity. The presence of the methoxy and hydroxyl groups enhances hydrogen bonding interactions, which can stabilize enzyme-substrate complexes. Additionally, its aromatic structure contributes to unique π-π stacking interactions, influencing the enzyme's substrate specificity and altering the dynamics of amine metabolism.