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R(−)-Deprenyl hydrochloride (CAS 14611-52-0) - chemical structure image
Molecular structure of R(−)-Deprenyl hydrochloride, CAS Number: 14611-52-0
R(−)-Deprenyl hydrochloride (CAS 14611-52-0) - chemical structure image
Molecular structure of R(−)-Deprenyl hydrochloride, CAS Number: 14611-52-0
Molecular structure of R(−)-Deprenyl hydrochloride, CAS Number: 14611-52-0

R(−)-Deprenyl hydrochloride (CAS 14611-52-0)

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Alternate Names:
Selegiline hydrochloride
Application:
R(−)-Deprenyl hydrochloride is a neuroprotective agent and inhibitor of MAO-B
CAS Number:
14611-52-0
Purity:
98%
Molecular Weight:
223.74
Molecular Formula:
C13H17N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

R(−)-Deprenyl hydrochloride is the hydrochloride salt preparation of R(−)-Deprenyl, an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. R(−)-Deprenyl demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. R(−)-Deprenyl also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B. The GAPDH (glyceraldehyde-3-phosphate dehydrogenase) enzyme is implicated as a potential mediator of R(−)-Deprenyl-induced neuroprotection - reported to interact with proteins implicated in neurodegeneration and to activate transcription in neuronal cells, GAPDH has also been shown to directly interact with CGP 3466, a close structural and functional analog of R(−)-Deprenyl.


R(−)-Deprenyl hydrochloride (CAS 14611-52-0) References

  1. Metabolic transformation plays a primary role in the psychostimulant-like discriminative-stimulus effects of selegiline [(R)-(-)-deprenyl].  |  Yasar, S., et al. 2006. J Pharmacol Exp Ther. 317: 387-94. PMID: 16352699
  2. Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism.  |  Tatton, WG. and Greenwood, CE. 1991. J Neurosci Res. 30: 666-72. PMID: 1686284
  3. A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl.  |  Quinn, LP., et al. 2007. J Neurosci Methods. 164: 43-9. PMID: 17498809
  4. The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B.  |  Quinn, LP., et al. 2008. Br J Pharmacol. 154: 226-33. PMID: 18332857
  5. Radiosynthesis and in vivo evaluation of [11C]-labelled pyrrole-2-carboxamide derivates as novel radioligands for PET imaging of monoamine oxidase A.  |  De Bruyne, S., et al. 2010. Nucl Med Biol. 37: 459-67. PMID: 20447558
  6. Cerebral ischemia-reperfusion induces GAPDH S-nitrosylation and nuclear translocation.  |  Li, C., et al. 2012. Biochemistry (Mosc). 77: 671-8. PMID: 22817468
  7. Loss of schooling behavior in cavefish through sight-dependent and sight-independent mechanisms.  |  Kowalko, JE., et al. 2013. Curr Biol. 23: 1874-83. PMID: 24035545
  8. Monoamine oxidase (MAO) inhibitory activity: 3-phenylcoumarins versus 4-hydroxy-3-phenylcoumarins.  |  Delogu, GL., et al. 2014. ChemMedChem. 9: 1672-6. PMID: 24782464
  9. The effect of deprenyl (selegiline) on the natural history of Parkinson's disease.  |  Tetrud, JW. and Langston, JW. 1989. Science. 245: 519-22. PMID: 2502843
  10. In vitro antifungal activity of antipsychotic drugs and their combinations with conventional antifungals against Scedosporium and Pseudallescheria isolates.  |  Homa, M., et al. 2015. Med Mycol. 53: 890-5. PMID: 26316212
  11. Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain.  |  Ng, KP., et al. 2017. Alzheimers Res Ther. 9: 25. PMID: 28359327
  12. Regulation of endothelial cell survival and death by the MAP kinase/ERK kinase kinase 3 - glyceraldehyde-3-phosphate dehydrogenase signaling axis.  |  Li, YQ., et al. 2019. Cell Signal. 58: 20-33. PMID: 30831195
  13. Clinical trial for Parkinson's disease?  |  Lewin, R. 1985. Science. 230: 527-8. PMID: 3931220
  14. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis.  |  Tatton, WG., et al. 1994. J Neurochem. 63: 1572-5. PMID: 7931312
  15. Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl.  |  Kragten, E., et al. 1998. J Biol Chem. 273: 5821-8. PMID: 9488718

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

R(−)-Deprenyl hydrochloride, 100 mg

sc-200742
100 mg
$32.00

R(−)-Deprenyl hydrochloride, 250 mg

sc-200742A
250 mg
$77.00

R(−)-Deprenyl hydrochloride, 1 g

sc-200742B
1 g
$281.00

how is the deprenyl 100 mg divided, ie, does it come in tablets?

Asked by: roadtaken
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Answered by: Technical Support
Date published: 2021-07-22
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Rated 5 out of 5 by from MihalikMihalik, et al. treated male rats with R(-)-deprenyl and found that the epididymis that was exposed to this drug had a higher sperm count and the females that mated with these rats gave birth to a greater number of offspring, when compared to the control. -SCBT Publication Review
Date published: 2015-03-21
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R(andminus)-Deprenyl hydrochloride | CAS 14611-52-0 is rated 5.0 out of 5 by 1.
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