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Ro 16-6491 (CAS 94319-79-6)

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Application:
Ro 16-6491 is a selective reversible MAO-B inhibitor devoid of indirect sympathomimetic activity
CAS Number:
94319-79-6
Molecular Weight:
235.1
Molecular Formula:
C9H11ClN2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ro 16-6491 is a selective, reversible MAO-B (monoamine oxidase- β) inhibitor which is devoid of indirect sympathomimetic activity.


Ro 16-6491 (CAS 94319-79-6) References

  1. Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid.  |  Geha, RM., et al. 2001. J Biol Chem. 276: 9877-82. PMID: 11134050
  2. Synthesis and characterization of radioiodinated MD-230254: a new ligand for potential imaging of monoamine oxidase B activity by single photon emission computed tomography.  |  Hirata, M., et al. 2002. Chem Pharm Bull (Tokyo). 50: 609-14. PMID: 12036014
  3. An in vitro interethnic comparison of monoamine oxidase activities between Japanese and Caucasian livers using rizatriptan, a serotonin receptor 1B/1D agonist, as a model drug.  |  Iwasa, T., et al. 2003. Br J Clin Pharmacol. 56: 537-44. PMID: 14651728
  4. Metabolic transformation plays a primary role in the psychostimulant-like discriminative-stimulus effects of selegiline [(R)-(-)-deprenyl].  |  Yasar, S., et al. 2006. J Pharmacol Exp Ther. 317: 387-94. PMID: 16352699
  5. Neural progenitor cells are protected against MPTP by MAO-B inhibitors.  |  He, XJ., et al. 2008. Neurotoxicology. 29: 1141-6. PMID: 18606181
  6. Characterization of [3H]Ro 16-6491 binding to digitonin solubilized monoamine oxidase-B and purification of the enzyme from human platelets by affinity chromatography.  |  Cesura, AM., et al. 1990. Biochem Pharmacol. 39: 216-20. PMID: 2297358
  7. [3H]Ro 16-6491, a selective probe for affinity labelling of monoamine oxidase type B in human brain and platelet membranes.  |  Cesura, AM., et al. 1988. J Neurochem. 50: 1037-43. PMID: 3126263
  8. Interactions of the novel inhibitors of MAO-B Ro 19-6327 and Ro 16-6491 with the active site of the enzyme.  |  Cesura, AM., et al. 1988. Pharmacol Res Commun. 20 Suppl 4: 51-61. PMID: 3244727
  9. Synthesis and characterization of [125I]N-(2-aminoethyl)-4-iodobenzamide as a selective monoamine oxidase B inhibitor.  |  Rafii, H., et al. 1995. Nucl Med Biol. 22: 617-23. PMID: 7581172
  10. In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl.  |  Bondiolotti, GP., et al. 1995. Biochem Pharmacol. 50: 97-102. PMID: 7605351
  11. The effects of phenelzine and other monoamine oxidase inhibitor antidepressants on brain and liver I2 imidazoline-preferring receptors.  |  Alemany, R., et al. 1995. Br J Pharmacol. 114: 837-45. PMID: 7773544
  12. Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues.  |  Mullan, EL. and Williams, CH. 1994. J Neural Transm Suppl. 41: 307-11. PMID: 7931243
  13. Additive effects of glyburide and antidepressants in the forced swimming test: evidence for the involvement of potassium channel blockade.  |  Guo, W., et al. 1996. Pharmacol Biochem Behav. 54: 725-30. PMID: 8853196

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ro 16-6491, 200 mg

sc-200743
200 mg
$57.00

Ro 16-6491, 1 g

sc-200743A
1 g
$218.00