The chemical class of Mndal Inhibitors represents a specialized group of compounds engineered to target and inhibit the activity of proteins or enzymes associated with the Mndal gene. This gene, identified through meticulous genetic and molecular research, plays a significant role in numerous cellular processes. The function of the Mndal gene is complex and varies based on the cellular context and external environmental factors. Mndal Inhibitors are designed with a high degree of specificity, focusing on the inhibition of the biological functions associated with Mndal gene products. These inhibitors work by binding to the proteins or enzymes that are expressed as a result of Mndal gene activation. This binding process is critical as it directly influences the biochemical pathways in which the Mndal gene product is involved. The primary aim of these inhibitors is to modulate the activity of the Mndal gene product, thereby impacting the associated cellular functions and processes.
The development of Mndal Inhibitors is an intricate and interdisciplinary task, combining elements of molecular biology, biochemistry, and organic chemistry. The process begins with a comprehensive understanding of the structure and function of the target gene product. Advanced techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and computational molecular modeling are employed to achieve a detailed understanding of the target molecule. This foundational knowledge is crucial for the rational design of inhibitors that are not only effective in their interaction but also highly selective to their target. These inhibitors are generally small molecules, designed for efficient cellular penetration and to establish a stable and potent interaction with the target. The molecular design of these inhibitors is carefully optimized, ensuring strong hydrogen bonds, hydrophobic interactions, and van der Waals forces with the target molecule. The effectiveness of these inhibitors is evaluated through various biochemical assays in vitro. These assays are vital for determining the inhibitors' ability to inhibit the activity of the gene product, assessing factors such as potency, specificity, and overall interaction dynamics. These studies provide essential insights into the behavior of the inhibitors, laying the groundwork for further research into their interaction mechanisms and impact on cellular pathways.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interferes with DNA-dependent RNA polymerase by binding to DNA and preventing RNA synthesis, which can inhibit transcription globally. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
A potent inhibitor of RNA polymerase II, which is responsible for transcribing mRNA, potentially reducing gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A diterpene triepoxide that has been shown to inhibit the transcription of various genes by affecting RNA polymerase II activity. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits RNA polymerase II by blocking the transition from initiation to elongation during mRNA synthesis, affecting gene expression. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Initially known as a cyclin-dependent kinase inhibitor, it also inhibits transcription elongation by RNA polymerase II, impacting gene transcription. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
An adenosine analog that disrupts RNA synthesis by prematurely terminating mRNA chain elongation, potentially reducing gene expression. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
A natural product that has been found to inhibit translation initiation, leading to downregulation of protein synthesis and gene expression. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
Works by inhibiting the initial elongation step of protein synthesis, which can lead to decreased gene expression at the translational level. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Inhibits peptide bond formation by binding to the 60S ribosomal subunit, which can lead to decreased gene expression on the translation level. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis by interfering with the translocation step in the ribosome, leading to global reduction in gene expression. |