MMP-3 Activators
Common MMP-3 Activators include, but are not limited to PMA CAS 16561-29-8, Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, β-Estradiol CAS 50-28-2, Retinoic Acid, all trans CAS 302-79-4 and Resveratrol CAS 501-36-0.
MMP-3 activators belong to a category of compounds or molecules that can stimulate the activity of Matrix Metalloproteinase-3 (MMP-3), also known as Stromelysin-1. MMP-3 is a member of the matrix metalloproteinase family, which comprises a group of enzymes responsible for the degradation of various components of the extracellular matrix. These enzymes are essential for tissue remodeling, wound healing, and various physiological processes. MMP-3, in particular, is implicated in the degradation of proteoglycans, collagen, and other extracellular matrix components. Its activation can have significant effects on tissue homeostasis and repair.
The activation of MMP-3 can occur through various mechanisms, including interactions with endogenous or exogenous compounds. These activators can initiate intracellular signaling pathways that ultimately lead to increased MMP-3 expression or activation. In some cases, inflammatory mediators, growth factors, or mechanical stress can serve as activators for MMP-3. Understanding the regulation of MMP-3 activity is crucial in the context of tissue remodeling, inflammation, and diseases such as osteoarthritis and rheumatoid arthritis, where MMP-3 dysregulation can contribute to pathological tissue degradation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Known to activate protein kinase C (PKC), leading to increased MMP-3 expression in certain cell types. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Bacterial endotoxin that can stimulate immune cells to release pro-inflammatory cytokines, leading to increased MMP-3 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Hormone that can modulate MMP-3 expression in tissues like the endometrium. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Derivative of vitamin A that can influence MMP-3 expression in certain contexts. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
May influence MMP-3 expression by altering acetylation patterns of histones at its promoter region. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
GPCR agonist triggering MAPK pathways and increased MMP-3 mRNA levels via AP-1. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Second messenger activates calmodulin dependent kinases and phosphorylates transcription factors affecting MMP-3 levels. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid that may indirectly repress or activate MMP-3 through effects on other factors. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Binds EP receptors increasing cAMP and activating PKA pathway, leading to CREB activation of MMP-3. | ||||||