mKIAA1530 inhibitors represent a class of chemical compounds that specifically target the molecular functions of the mKIAA1530 protein, a protein that is still being explored in the context of its structural and biochemical role within cells. These inhibitors are designed to modulate the activity of mKIAA1530, which may be involved in processes such as protein-protein interactions, signal transduction, or other cellular functions. The design and synthesis of mKIAA1530 inhibitors often involve a detailed understanding of the protein's three-dimensional structure, active sites, and binding pockets. Researchers typically utilize computational modeling and structure-based drug design techniques to predict how these inhibitors interact with the protein at the molecular level. Such inhibitors often consist of small molecules engineered to fit precisely within the protein's active sites, thereby altering its function by either blocking or modifying its natural activity.
On a chemical level, mKIAA1530 inhibitors may feature a variety of functional groups that can interact with different amino acid residues in the protein. These interactions may include hydrogen bonding, van der Waals forces, and hydrophobic or electrostatic interactions. The inhibitors can be fine-tuned for selectivity and potency by modifying their chemical scaffolds, enhancing their binding affinity to mKIAA1530, while minimizing non-specific interactions with other proteins. This process typically involves iterative cycles of synthesis and testing, where the structural characteristics of both the inhibitor and the protein are optimized to achieve the desired level of inhibition. The chemistry of mKIAA1530 inhibitors is therefore an evolving field, with researchers continuing to explore how different molecular frameworks and functional groups contribute to their inhibitory properties.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
Inhibitor of the p97 ATPase, which is involved in ubiquitin-mediated protein degradation. Since protein ubiquitination can be linked to DNA repair mechanisms, this compound can indirectly affect the function of mKIAA1530. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
Inhibitor of NEDD8-activating enzyme which is crucial for the neddylation of cullin proteins that regulate ubiquitin ligase activity. By inhibiting this enzyme, the ubiquitin ligase activity can be impaired, indirectly affecting mKIAA1530's role in protein ubiquitination. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor that affects protein degradation. Since mKIAA1530 is involved in protein ubiquitination, inhibition of the proteasome can indirectly affect its function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome and calpain inhibitor, which interferes with the degradation of ubiquitinated proteins, potentially impacting the cellular processes associated with mKIAA1530. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
A specific inhibitor of the proteasome that can prevent the degradation of ubiquitinated proteins, indirectly influencing mKIAA1530's role in protein ubiquitination. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
An inhibitor of the ubiquitin-activating enzyme E1, leading to a decrease in ubiquitin-conjugated proteins which can indirectly impact mKIAA1530's function in protein ubiquitination. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Inhibits the thioredoxin reductase, which can affect the redox state in cells; this change can influence various cellular processes including those involved in DNA repair, which could impact mKIAA1530's function. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibitor of DNA topoisomerase I, causing DNA damage that could indirectly require the DNA repair mechanisms where mKIAA1530 is involved. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A diterpene triepoxide that can inhibit transcription factors and induce DNA damage, possibly necessitating the DNA repair processes associated with mKIAA1530. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitor, impairs single-strand break repair, necessitating other DNA repair mechanisms which mKIAA1530 might be involved in, thus indirectly affecting its function. | ||||||