MIPEP Inhibitors
Chemical inhibitors of MIPEP exert their inhibitory effects through various mechanisms that impinge upon the protein's mitochondrial context and its ATP-dependent catalytic activity. Oligomycin A, for example, targets the mitochondrial ATP synthase, substantially reducing the ATP pool that MIPEP relies on for its function. Similarly, Antimycin A and Rotenone disrupt the mitochondrial electron transport chain at complexes III and I, respectively, leading to a decrease in ATP production, which is essential for MIPEP's activity. Sodium azide's inhibition of cytochrome c oxidase in complex IV further diminishes ATP synthesis, challenging MIPEP's energy-dependent operations. CCCP, acting as an uncoupler, dissolves the proton gradient across the mitochondrial membrane, another blow to ATP generation and, by extension, to MIPEP's activity.
Compounds that interfere with the metal ions crucial for MIPEP's structure and function also play a role in its inhibition. Zinc chloride can directly inhibit MIPEP by competing with the metal ions required for its metalloprotease domain. In a similar vein, Cadmium chloride can displace these essential metals, obstructing MIPEP's enzymatic processes. 2-Thenoyltrifluoroacetone chelates Mg2+ ions, which could incapacitate MIPEP's metal-dependent enzymatic action. The broad actions of Carboxin and Allopurinol, through their effects on succinate dehydrogenase and xanthine oxidase respectively, lead to an indirect suppression of MIPEP by altering mitochondrial function and ATP availability. Tetracycline's calcium binding can indirectly impact MIPEP by disrupting mitochondrial calcium homeostasis. Auranofin, by targeting thioredoxin reductase, can induce a shift in the redox state within the mitochondria, a condition that is likely to inhibit the proper function of mitochondrial proteins such as MIPEP.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin A inhibits mitochondrial ATP synthase (complex V), leading to decreased ATP production. As MIPEP is located in the mitochondria and is ATP-dependent for its peptidase activity, the reduction in ATP availability can inhibit MIPEP function. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits succinate dehydrogenase (complex II) in the mitochondrial respiratory chain, which could decrease the mitochondrial membrane potential. This can indirectly inhibit MIPEP by disrupting its mitochondrial context and energy-dependent functions. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A binds to cytochrome b and inhibits complex III of the mitochondrial electron transport chain, leading to reduced ATP production. Reduced ATP levels can inhibit ATP-dependent enzymes like MIPEP. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By impairing the electron transport chain, it decreases ATP synthesis, which is necessary for MIPEP's catalytic activity. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits cytochrome c oxidase in complex IV of the electron transport chain, reducing ATP production. This can inhibit the ATP-dependent catalytic function of MIPEP. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc chloride can bind to and inhibit metalloenzymes. As MIPEP has a metalloprotease domain requiring metal ions for its activity, the presence of zinc can inhibit its enzymatic function. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP uncouples oxidative phosphorylation by dissipating the proton gradient across the mitochondrial membrane, leading to reduced ATP production and potentially inhibiting ATP-dependent enzymes like MIPEP. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Allopurinol is known to inhibit xanthine oxidase, and while not directly inhibiting MIPEP, its action leads to altered purine metabolism and could indirectly affect the levels of ATP, thereby inhibiting MIPEP function. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
This compound chelates Mg2+ ions, which are essential for the activity of various ATPases. By chelating Mg2+, it could indirectly inhibit the ATPase activity of enzymes like MIPEP. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Tetracycline can bind to calcium ions, and since calcium homeostasis is important for mitochondrial function, this binding could indirectly inhibit MIPEP by altering its mitochondrial environment. | ||||||