METTL1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SIRT2 Inhibitor II, AK-1 | 330461-64-8 | sc-364619 | 10 mg | $171.00 | ||
AK-1 is a small molecule inhibitor of METTL1 that interferes with its methyltransferase activity, specifically targeting its SAM-binding site. It disrupts the formation of the METTL1-METTL16 complex, inhibiting m7G methylation of tRNAs and regulating gene expression at the translational level. | ||||||
MS023 | 1831110-54-3 | sc-507463 | 5 mg | $165.00 | ||
MS023 is a small molecule METTL1 inhibitor that competes with SAM (S-adenosylmethionine) for binding to METTL1's active site. By blocking the SAM binding, it hinders the methylation of tRNA and mRNA, impacting gene expression. | ||||||
UNC 0224 | 1197196-48-7 | sc-362816 sc-362816A | 10 mg 50 mg | $194.00 $816.00 | ||
UNC0224 is a chemical inhibitor of METTL1 that disrupts its methyltransferase activity. It interferes with the SAM binding site of METTL1, inhibiting its ability to methylate m7G in tRNA and modulating translation. | ||||||
N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine | 1453071-47-0 | sc-500552 | 10 mg | $430.00 | ||
N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine is a chemical inhibitor of METTL1 that blocks its methyltransferase activity. It disrupts the binding of SAM to METTL1, leading to impaired m7G methylation of tRNAs and translational control. | ||||||
2-(Dimethylamino)guanosine | 2140-67-2 | sc-220667A sc-220667B sc-220667 sc-220667C sc-220667D | 5 mg 10 mg 25 mg 50 mg 100 mg | $230.00 $300.00 $380.00 $615.00 $1095.00 | 2 | |
N2,N2-Dimethylguanosine is a competitive METTL1 inhibitor that mimics the substrate of METTL1. It interferes with the methylation of guanosine at the N2 position on tRNAs, affecting translation and gene expression. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
S-(5'-Adenosyl)-L-homocysteine (SAH) is an inhibitor of METTL1 that accumulates as a byproduct during SAM-dependent methylation reactions. Elevated SAH levels inhibit METTL1's methyltransferase activity, impacting tRNA methylation. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine is a natural compound that can inhibit METTL1 by competing with SAM for binding. It interferes with the methylation of tRNA and mRNA, regulating gene expression at the translational level. | ||||||
Amprolium HCl | 137-88-2 | sc-391655 sc-391655A | 25 g 100 g | $82.00 $255.00 | 1 | |
Amprolium is an inhibitor of METTL1, which disrupts its methyltransferase activity. It affects the methylation of m7G in tRNAs, influencing translation and gene expression. | ||||||
Amikacin (free base) | 37517-28-5 | sc-278692 sc-278692A | 1 g 5 g | $68.00 $162.00 | 2 | |
Amikacin is an aminoglycoside antibiotic that can inhibit METTL1 by interfering with its methylation of m7G in tRNAs. It affects translational fidelity and gene expression. | ||||||