Molecular structure of SIRT2 Inhibitor II, AK-1, CAS Number: 330461-64-8
SIRT2 Inhibitor II, AK-1 (CAS 330461-64-8)
Alternate Names:
3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide
Application:
SIRT2 Inhibitor II, AK-1 is a selective SIRT2 inhibitor
CAS Number:
330461-64-8
Molecular Weight:
403.45
Molecular Formula:
C19H21N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SIRT2 Inhibitor II, AK-1 is a compound with specificity towards the inhibition of the enzyme SIRT2, a member of the sirtuin family of NAD+-dependent deacetylases. In research applications, SIRT2 Inhibitor II, AK-1 is primarily used to elucidate the biological functions of SIRT2, including its role in cell cycle regulation and cellular response to DNA damage. By inhibiting SIRT2 activity, researchers can study the consequences of reduced protein deacetylation on various cellular processes, which is valuable for understanding the molecular mechanisms underlying age-related diseases and neurodegeneration. SIRT2 Inhibitor II, AK-1 is also employed in the investigation of the sirtuin′s involvement in metabolic regulation and the maintenance of genomic stability.
SIRT2 Inhibitor II, AK-1 (CAS 330461-64-8) References
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- Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1. | Wu, F., et al. 2010. FASEB J. 24: 2464-74. PMID: 20237298
- SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. | Luthi-Carter, R., et al. 2010. Proc Natl Acad Sci U S A. 107: 7927-32. PMID: 20378838
- Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors. | Khanfar, MA., et al. 2014. Eur J Med Chem. 76: 414-26. PMID: 24602787
- AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. | Cheon, MG., et al. 2015. Cancer Lett. 356: 637-45. PMID: 25312940
- The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. | Chen, X., et al. 2015. PLoS One. 10: e0116919. PMID: 25608039
- Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors. | Khanfar, MA., et al. 2015. ACS Med Chem Lett. 6: 607-11. PMID: 26005542
- AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia. | Lee, SD., et al. 2016. Cancer Lett. 373: 138-145. PMID: 26808575
- AK-1, a Sirt2 inhibitor, alleviates carbon tetrachloride-induced hepatotoxicity in vivo and in vitro. | Zhou, Z., et al. 2020. Toxicol Mech Methods. 30: 324-335. PMID: 32063085
- SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells. | Lim, J., et al. 2020. Int J Mol Sci. 21: PMID: 32213867
- The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene? | Zhang, L., et al. 2020. Front Oncol. 10: 1721. PMID: 33014852
- Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders. | Chen, X., et al. 2021. Front Neurosci. 15: 614107. PMID: 34108853
- MYO1F regulates antifungal immunity by regulating acetylation of microtubules. | Sun, W., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34301894
- Sirtuins: Research advances on the therapeutic role in acute kidney injury. | Huang, C., et al. 2022. Phytomedicine. 101: 154122. PMID: 35490494
- SIRT2 plays complex roles in neuroinflammation neuroimmunology-associated disorders. | Lu, W., et al. 2023. Front Immunol. 14: 1174180. PMID: 37215138
Inhibitor of:
Integrin α11, SIRT2, SIRT5, and SPRN.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SIRT2 Inhibitor II, AK-1, 10 mg | sc-364619 | 10 mg | $174.00 |