Meprin A alpha Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TAPI-0 | 143457-40-3 | sc-203410 sc-203410A | 1 mg 5 mg | $269.00 $1248.00 | 15 | |
TAPI-0, functioning as a Meprin A alpha, showcases remarkable reactivity as an acid halide, primarily through its selective electrophilic nature. The compound's unique ability to form transient complexes with nucleophiles accelerates reaction kinetics, facilitating rapid hydrolysis. Its distinct conformational flexibility allows for varied molecular interactions, while its solvation dynamics contribute to its stability in diverse environments, making it a fascinating subject for further exploration in chemical reactivity. | ||||||
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $199.00 $632.00 | 8 | |
A competitive inhibitor that binds directly to the active site of Meprin Aα, chelating the metal ion, and preventing substrate binding. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
It chelates zinc in the active site of Meprin Aα, altering its structure and making it unavailable for substrate interaction. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
A hydroxamate-based inhibitor that forms a tight bond with the zinc ion in the active site of Meprin Aα, preventing substrate binding and cleavage. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Interacts with the active site of Meprin Aα, chelating the zinc ion, and hence preventing substrate-enzyme interaction. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Another hydroxamate-based molecule; it chelates the zinc ion in the Meprin Aα active site, inhibiting the proteolytic activity of the enzyme. | ||||||
TAPI-2 | 187034-31-7 | sc-205851 sc-205851A | 1 mg 5 mg | $286.00 $1019.00 | 15 | |
Binds to Meprin Aα and chelates the metal ion in the active site, restricting its proteolytic function. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
While E-64 primarily targets cysteine proteases, it can indirectly modulate the environment of Meprin Aα, affecting its function. | ||||||
o-Phenanthroline monohydrate | 5144-89-8 | sc-202256 sc-202256A | 1 g 25 g | $43.00 $188.00 | 1 | |
Acts as a metal chelator, binding to the zinc in Meprin Aα, leading to enzyme structural changes and diminished activity | ||||||