Molecular structure of TAPI-0, CAS Number: 143457-40-3
TAPI-0 (CAS 143457-40-3)
See product citations (15)
Alternate Names:
TAPI-0 is also known as TNF-α Protease Inhibitor-0.
Application:
TAPI-0 is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM).
CAS Number:
143457-40-3
Purity:
≥97%
Molecular Weight:
456.54
Molecular Formula:
C24H32N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TAPI-0 is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-a converting enzyme/ADAM17 IC50 = 100 nM). TAPI-0 blocks spontaneous and PMA-induced release of TNF-a in transfected COS 7 cells. TAPI-0 blocks the maturation of cytokines, soluble cytokine receptors, and other proteins that require the action of proteases. TAPI-0 is also known as N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TAPI-0 (TNF-± processing inhibitor-0), and TNF-α Protease Inhibitor-0.
TAPI-0 (CAS 143457-40-3) References
- Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. | Balakrishnan, A., et al. 2006. J Biol Chem. 281: 16691-9. PMID: 16565079
- Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation. | Fukaya, S., et al. 2013. Lab Invest. 93: 72-80. PMID: 23147225
- Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation. | Choi, JY., et al. 2013. J Pharmacol Exp Ther. 344: 447-58. PMID: 23197771
- Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis. | Gandhi, R., et al. 2014. Am J Physiol Renal Physiol. 307: F205-21. PMID: 24829508
- A comparative study on inhibition of total astragalus saponins and astragaloside IV on TNFR1-mediated signaling pathways in arterial endothelial cells. | Liu, QS., et al. 2014. PLoS One. 9: e101504. PMID: 24991819
- Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation. | Lee, EJ., et al. 2014. J Immunol. 193: 2384-93. PMID: 25049354
- Hydroxy-Safflower Yellow A inhibits the TNFR1-Mediated Classical NF-κB Pathway by Inducing Shedding of TNFR1. | Wang, H., et al. 2016. Phytother Res. 30: 790-6. PMID: 26806653
- Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes. | Euler, G., et al. 2021. Cardiovasc Drugs Ther. 35: 353-365. PMID: 33400052
- Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma. | Chen, JY., et al. 2021. Biomed Pharmacother. 140: 111701. PMID: 34051616
- Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage. | Kaneko, T., et al. 2022. J Bone Miner Metab. 40: 196-207. PMID: 34751824
- Interval-Based Secretomics Unravels Acute-Phase Response in Hepatocyte Model Systems. | Knecht, S., et al. 2022. Mol Cell Proteomics. 21: 100241. PMID: 35525403
- Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats. | Yu, Y., et al. 2022. Front Physiol. 13: 1052304. PMID: 36439267
- A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor. | Müllberg, J., et al. 1995. J Immunol. 155: 5198-205. PMID: 7594530
- Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. | Mohler, KM., et al. 1994. Nature. 370: 218-20. PMID: 8028669
- Membrane protein secretases. | Hooper, NM., et al. 1997. Biochem J. 321 (Pt 2): 265-79. PMID: 9020855
Inhibitor of:
Meprin A alpha, MMP, and TACE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAPI-0, 1 mg | sc-203410 | 1 mg | $269.00 | |||
TAPI-0, 5 mg | sc-203410A | 5 mg | $1248.00 |