megalin Activators
Megalin, a multifunctional endocytic receptor predominantly expressed in renal proximal tubule cells, plays a crucial role in the reabsorption of filtered proteins. The identified chemicals presented here, albeit not proven direct activators, modulate megalin activity through intricate cellular pathways. Gossypol, a natural compound, indirectly activates megalin by impacting the PI3K/AKT pathway, which regulates megalin expression and function in specific cellular contexts. Resveratrol, a polyphenol, indirectly activates megalin through its influence on SIRT1 activity, affecting pathways linked to megalin expression and trafficking. Sulforaphane, found in cruciferous vegetables, activates NRF2, indirectly promoting megalin expression by modulating cellular redox status and enhancing endocytic capacity. AICAR, an AMPK activator, indirectly activates megalin by modulating AMPK-dependent pathways, impacting megalin expression and trafficking in response to altered energy status.
Troglitazone, a PPARγ agonist, indirectly activates megalin by influencing PPARγ-dependent pathways, altering megalin expression and function transcriptionally. Raloxifene, a selective estrogen receptor modulator, indirectly activates megalin by modulating estrogen receptor signaling, impacting megalin expression and function in a hormone-dependent manner. Dasatinib, a tyrosine kinase inhibitor, indirectly activates megalin through its effects on Src family kinases, influencing megalin expression and function kinase-dependently. Parthenolide, found in feverfew, indirectly activates megalin by modulating NF-κB signaling, impacting megalin expression and function through altered transcriptional regulation. GW501516, a PPARδ agonist, indirectly activates megalin by influencing PPARδ-dependent pathways, altering megalin expression and function transcriptionally. Betulinic acid, a natural compound, indirectly activates megalin through its effects on the STAT3 pathway, influencing megalin expression and function transcriptionally. C646, a p300/CBP inhibitor, indirectly activates megalin by affecting histone acetylation, influencing megalin expression and function epigenetically. In conclusion, while direct megalin activators remain elusive, these chemicals show promise in influencing megalin activity through intricate cellular pathways, providing a foundation for further exploration into their regulatory roles in megalin-mediated endocytosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $114.00 $225.00 | 12 | |
Gossypol, a natural compound, affects the PI3K/AKT pathway. By modulating this pathway, gossypol indirectly activates megalin, as PI3K/AKT signaling plays a role in regulating megalin expression and function in certain cellular contexts, enhancing its endocytic activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, influences SIRT1 activity. Its impact on SIRT1 can indirectly activate megalin by affecting cellular pathways linked to megalin expression and trafficking, ultimately enhancing endocytic processes through modulation of intracellular signaling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, activates NRF2. Through NRF2 activation, sulforaphane indirectly promotes megalin expression by modulating cellular redox status, resulting in enhanced endocytic capacity through NRF2-mediated regulation of megalin-related pathways. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR, an AMPK activator, influences AMPK-dependent pathways. Indirectly, AICAR can activate megalin by modulating AMPK-related cellular processes, impacting megalin expression and trafficking, thereby enhancing endocytic activity in response to altered energy status. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone, a PPARγ agonist, affects PPARγ-dependent pathways. Indirectly, troglitazone can activate megalin by modulating PPARγ-related cellular processes, influencing megalin expression and function, leading to enhanced endocytic capacity through altered transcriptional regulation. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Raloxifene, a selective estrogen receptor modulator, influences estrogen receptor signaling. Indirectly, raloxifene can activate megalin by modulating estrogen receptor-dependent pathways, impacting megalin expression and function, leading to enhanced endocytic processes. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib, a tyrosine kinase inhibitor, affects Src family kinases. Indirectly, dasatinib can activate megalin by modulating Src kinase-dependent pathways, influencing megalin expression and function, leading to enhanced endocytic capacity through altered kinase activity. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide, found in feverfew, affects NF-κB signaling. Indirectly, parthenolide can activate megalin by modulating NF-κB-dependent pathways, impacting megalin expression and function, leading to enhanced endocytic capacity through altered transcriptional regulation. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516, a PPARδ agonist, influences PPARδ-dependent pathways. Indirectly, GW501516 can activate megalin by modulating PPARδ-related cellular processes, impacting megalin expression and function, leading to enhanced endocytic capacity through altered transcriptional regulation. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid, a natural compound, affects the STAT3 pathway. Indirectly, betulinic acid can activate megalin by modulating STAT3-dependent pathways, influencing megalin expression and function, leading to enhanced endocytic capacity through altered transcriptional regulation. | ||||||