MCJ Inhibitors
MCJ inhibitors represent a chemical class of compounds that specifically target the mitochondrial carrier homolog 1 (MCJ), a protein localized within the inner mitochondrial membrane. MCJ plays a critical role in regulating mitochondrial respiration and metabolic flux. It is part of the solute carrier family, specifically SLC25, which is involved in transporting molecules across the mitochondrial membrane. MCJ acts as a negative regulator of complex I in the mitochondrial electron transport chain, modulating the efficiency of ATP production by controlling the rate of oxidative phosphorylation. The function of MCJ has been closely studied in the context of its influence on cellular energy dynamics, as well as its effect on mitochondrial membrane potential. Inhibiting MCJ can lead to an upregulation of mitochondrial respiration, enhancing the flow of electrons through complex I and increasing the efficiency of cellular respiration.
From a biochemical standpoint, MCJ inhibitors operate by disrupting the interaction between MCJ and complex I of the electron transport chain, allowing for greater electron flow and increased ATP synthesis. The precise structural characteristics of these inhibitors are of great interest, as they must bind selectively to MCJ without interfering with other mitochondrial transporters or complexes. The specificity of these compounds is essential for maintaining mitochondrial integrity and avoiding unintended effects on cellular homeostasis. Investigating the binding kinetics and affinity of various MCJ inhibitors can provide insight into their capacity to modulate mitochondrial functions effectively. By influencing mitochondrial energetics, these inhibitors can alter cellular metabolic profiles, especially under conditions where mitochondrial function is tightly regulated or under metabolic stress, thus offering valuable insight into the fundamental processes of energy regulation at the cellular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, may lead to an increase in acetylated histones, thereby loosening chromatin structure and rendering the MCJ promoter less accessible for transcriptional machinery, resulting in decreased MCJ expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate may inhibit histone deacetylation, which could result in hyperacetylation of histone proteins near the MCJ gene, reducing the transcriptional activity and leading to diminished MCJ expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Known as 5-Aza-2′-Deoxycytidine, this compound may prevent methylation of the MCJ gene promoter by inhibiting DNA methyltransferases, thereby leading to an open chromatin state and reduced transcription of the MCJ gene. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid could decrease MCJ expression by inhibiting histone deacetylase enzymes, which may cause an accumulation of acetylated histones and a subsequent decrease in MCJ gene transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A can bind to DNA and interfere with the binding of transcription factors to the MCJ gene promoter, leading to a reduction in the initiation of MCJ gene transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid may reduce MCJ expression through inhibition of histone deacetylase activity, which could result in elevated levels of acetylated histones and a corresponding reduction in transcription from the MCJ gene. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram could lower MCJ expression by interfering with the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, which may play a role in the transcriptional control of the MCJ gene. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
By inhibiting MEK, PD 98059 could disrupt the MAPK/ERK pathway, which is implicated in the transcriptional control of various genes, including MCJ, potentially leading to decreased MCJ expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002, by inhibiting PI3K, could downregulate the PI3K/Akt pathway and its downstream effects on transcription factors and genes, leading to a reduction in the expression levels of MCJ. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is crucial for protein synthesis. Its inhibition could lead to a general decrease in protein synthesis including that of MCJ, thereby lowering MCJ protein levels. | ||||||