MC1-R Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Melanocyte stimulating hormone | 581-05-5 | sc-364762 sc-364762A sc-364762B | 1 mg 5 mg 25 mg | $84.00 $210.00 $926.00 | ||
α-Melanocyte stimulating hormone (α-MSH) acts as a potent agonist for the MC1-R receptor, initiating a cascade of intracellular signaling pathways. Its unique peptide structure facilitates specific interactions with receptor binding sites, leading to the activation of adenylate cyclase and increased cAMP levels. This modulation of signaling pathways influences melanogenesis and skin pigmentation. Additionally, α-MSH exhibits distinct stability in physiological conditions, enhancing its functional efficacy in cellular environments. | ||||||
BMS 470539 dihydrochloride | 457893-92-4 | sc-362716 sc-362716A sc-362716B | 10 mg 50 mg 100 mg | $428.00 $1714.00 $3264.00 | 4 | |
BMS 470539 dihydrochloride selectively targets the MC1-R receptor, exhibiting high affinity and specificity. Its unique structural features enable it to stabilize receptor conformation, promoting effective G-protein coupling. This interaction triggers downstream signaling cascades, notably enhancing intracellular calcium mobilization and influencing gene expression. The compound's robust binding kinetics and resistance to enzymatic degradation further contribute to its prolonged activity within cellular systems, making it a noteworthy candidate for exploring receptor dynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin indirectly activates MC1-R by elevating intracellular cAMP levels. Although it does not bind directly to MC1-R, its effect on cAMP levels can enhance MC1-R mediated signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, a nonspecific inhibitor of phosphodiesterases, indirectly activates MC1-R by preventing the breakdown of cAMP. Elevated cAMP levels can amplify the signaling downstream of MC1-R activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP is a cAMP analogue that can mimic the intracellular effects of MC1-R activation. It bypasses the receptor and directly activates cAMP-dependent pathways, influencing melanogenesis. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
PDE4 inhibitors, such as Rolipram, increase cAMP levels by inhibiting its breakdown. This action indirectly activates the pathways downstream of MC1-R, enhancing melanin synthesis. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can indirectly influence MC1-R signaling by modulating cAMP levels in certain cellular contexts, thereby impacting melanogenesis. | ||||||
L-Tyrosine | 60-18-4 | sc-473512 sc-473512A sc-473512B sc-473512C | 100 g 250 g 1 kg 5 kg | $51.00 $209.00 $1637.00 $8165.00 | 1 | |
L-tyrosine, a precursor of melanin, can indirectly enhance MC1-R signaling by providing the necessary substrate for melanin synthesis. While it does not directly activate MC1-R, its availability is critical for the effectiveness of MC1-R mediated melanogenesis. | ||||||