Date published: 2025-9-26

1-800-457-3801

SCBT Portrait Logo
Seach Input

BMS 470539 dihydrochloride (CAS 457893-92-4)

0.0(0)
Write a reviewAsk a question

See product citations (4)

Alternate Names:
1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride
Application:
BMS 470539 dihydrochloride is a selective and potent agonist of melanocortin receptor (MC1-R)
CAS Number:
457893-92-4
Molecular Weight:
632.62
Molecular Formula:
C32H41N5O42HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

BMS 470539 dihydrochloride functions as a potent and selective inhibitor of a specific enzyme in cellular signaling pathways. This enzyme plays a role in regulating various cellular processes, including cell growth, proliferation, and survival. When BMS 470539 dihydrochloride interacts with the enzyme, it effectively blocks its activity, disrupting the signaling cascade and ultimately influencing the expression of genes involved in cell cycle progression and apoptosis. By inhibiting this enzyme, BMS 470539 dihydrochloride can modulate key cellular processes and pathways, leading to alterations in cell behavior and function. BMS 470539 dihydrochloride exerts its influence by binding to the active site of the enzyme, preventing its normal function and interfering with downstream signaling events. The mechanism of action of BMS 470539 dihydrochloride highlights its ability to modulate cellular processes at the molecular level, offering insights into regulating cellular signaling pathways.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences


BMS 470539 dihydrochloride (CAS 457893-92-4) References

  1. The melanoma-linked 'redhead' MC1R influences dopaminergic neuron survival.  |  Chen, X., et al. 2017. Ann Neurol. 81: 395-406. PMID: 28019657
  2. Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes.  |  Can, VC., et al. 2020. Eur J Pharmacol. 872: 172971. PMID: 32004526
  3. Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect.  |  Fan, K., et al. 2021. Theranostics. 11: 2670-2690. PMID: 33456566
  4. G Protein-Coupled Receptors in Osteoarthritis: A Novel Perspective on Pathogenesis and Treatment.  |  Wen, ZQ., et al. 2021. Front Cell Dev Biol. 9: 758220. PMID: 34746150
  5. Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease.  |  Cai, W., et al. 2022. Mol Neurodegener. 17: 16. PMID: 35197079

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BMS 470539 dihydrochloride, 10 mg

sc-362716
10 mg
$428.00

BMS 470539 dihydrochloride, 50 mg

sc-362716A
50 mg
$1714.00

BMS 470539 dihydrochloride, 100 mg

sc-362716B
100 mg
$3264.00