Matrin-3 Inhibitors
Matrin-3 inhibitors are a class of chemical compounds that specifically target the matrin-3 protein, a nuclear matrix-associated protein involved in various aspects of RNA metabolism, gene regulation, and nuclear structure maintenance. Matrin-3 plays a role in RNA binding, splicing, and the regulation of gene expression by interacting with both DNA and RNA within the nucleus. It is known to bind to specific nucleic acid sequences and to participate in RNA processing and stability, as well as in maintaining the integrity of the nuclear architecture. Inhibitors of matrin-3 disrupt its ability to bind RNA or interact with other nuclear components, thereby affecting the processes of RNA maturation and gene expression regulation.
The mechanism of action for matrin-3 inhibitors typically involves interfering with the RNA-binding domain or the protein-protein interaction domains of matrin-3. By blocking these critical functional sites, the inhibitors prevent matrin-3 from interacting with RNA or other nuclear proteins required for its regulatory functions. This disruption can lead to alterations in RNA processing, splicing, and transport, as well as changes in the structural organization of the nuclear matrix. Matrin-3 inhibitors are valuable tools for studying the intricate roles that this protein plays in maintaining nuclear function and regulating gene expression at the post-transcriptional level. These inhibitors help researchers explore how the loss of matrin-3 function impacts RNA metabolism and the broader consequences for cellular homeostasis and nuclear architecture.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CX-4945 | 1009820-21-6 | sc-364475 sc-364475A | 2 mg 50 mg | $183.00 $800.00 | 9 | |
CX-4945 is a direct matrin-3 inhibitor that targets the protein kinase CK2. By inhibiting CK2, CX-4945 disrupts the phosphorylation of matrin-3, leading to alterations in its cellular localization and function. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a direct matrin-3 inhibitor that targets the histone acetyltransferase p300/CBP. By inhibiting p300/CBP, C646 hinders the acetylation of matrin-3, affecting its interactions with other cellular components and modulating its functions. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a direct matrin-3 inhibitor that acts as a bromodomain and extraterminal domain (BET) protein inhibitor. By targeting BET proteins, JQ1 disrupts the binding of matrin-3 to chromatin, influencing its transcriptional regulation and cellular activities. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is an indirect matrin-3 inhibitor that targets the Raf/MEK/ERK signaling pathway. By inhibiting Raf kinases, Sorafenib modulates downstream signaling events, impacting cellular processes that indirectly affect the expression and function of matrin-3. | ||||||
BAY 87-2243 | 1227158-85-1 | sc-507483 | 5 mg | $100.00 | ||
BAY 87-2243 is an indirect matrin-3 inhibitor that targets the hypoxia-inducible factor (HIF) pathway. By inhibiting HIF-1α, BAY 87-2243 influences cellular responses to hypoxia, potentially affecting the expression and activity of matrin-3 under hypoxic conditions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an indirect matrin-3 inhibitor that targets the Rho-associated protein kinase (ROCK) pathway. By inhibiting ROCK, Y-27632 modulates cytoskeletal dynamics and cellular processes that indirectly impact the expression and function of matrin-3. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is an indirect matrin-3 inhibitor that disrupts microtubule dynamics. By inhibiting microtubule polymerization, Nocodazole induces changes in cellular architecture and intracellular transport, indirectly influencing the expression and localization of matrin-3. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is an indirect matrin-3 inhibitor that targets the mechanistic target of rapamycin (mTOR) pathway. By inhibiting mTOR, Torin 1 modulates cellular processes involved in protein synthesis and degradation, indirectly affecting the expression and turnover of matrin-3. | ||||||