Molecular structure of BAY 87-2243, CAS Number: 1227158-85-1
BAY 87-2243 (CAS 1227158-85-1)
Alternate Names:
1-cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]-piperazine
CAS Number:
1227158-85-1
Molecular Weight:
525.5
Molecular Formula:
C26H26F3N7O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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BAY 87-2243 (CAS 1227158-85-1) References
- BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. | Ellinghaus, P., et al. 2013. Cancer Med. 2: 611-24. PMID: 24403227
- BAY 87-2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. | Helbig, L., et al. 2014. Radiat Oncol. 9: 207. PMID: 25234922
- 18F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243. | Chang, E., et al. 2015. Clin Cancer Res. 21: 335-46. PMID: 25381339
- Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. | Schöckel, L., et al. 2015. Cancer Metab. 3: 11. PMID: 26500770
- BAY 87-2243 sensitizes hepatocellular carcinoma Hep3B cells to histone deacetylase inhibitors treatment via GSK-3β activation. | Li, YL., et al. 2019. Exp Ther Med. 17: 4547-4553. PMID: 31186678
- Metabolic study of hypoxia-inducible factor stabilizers BAY 87-2243, MK-8617, and PT-2385 in equine liver microsomes for doping control. | Philip, M., et al. 2022. Drug Test Anal. 14: 1703-1723. PMID: 35853151
- Targeting HIF-1α alleviates the inflammatory responses and rebuilds the CD4+ T cell subsets balance in the experimental autoimmune myasthenia gravis inflammation model via regulating cellular and humoral immunity. | Yu, L., et al. 2024. Life Sci. 336: 122287. PMID: 37995933
- PIEZO1 acts as a cancer suppressor by regulating the ROS/Wnt/β-catenin axis. | Bo, H., et al. 2024. Thorac Cancer. 15: 1007-1016. PMID: 38494915
- mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage. | Huang, Z., et al. 2024. BMC Mol Cell Biol. 25: 13. PMID: 38654163
- Fine-tuning of liposome integrity for differentiated transcytosis and enhanced antitumor efficacy. | Su, J., et al. 2024. J Control Release. 372: 69-84. PMID: 38866244
Inhibitor of:
Ear4, HID, HIF-1 alpha, IRS-1, Matrin-3, Rad21, RuvC, TADA2B, and ZNF645.Activator of:
1700011H14Rik, Histone H2A.X, and PDK3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAY 87-2243, 5 mg | sc-507483 | 5 mg | $100.00 |