MATE1 Inhibitors
The chemical class of MATE1 inhibitors comprises a diverse set of compounds designed to directly or indirectly modulate the function of MATE1, a key transporter involved in the cellular efflux of organic cations. Direct inhibitors, such as Cimetidine, Verapamil, and Famotidine, act by competitively binding to the substrate-binding site of MATE1, hindering the translocation of organic cations and influencing the pharmacokinetics of various drugs and endogenous substances. Pyrimethamine, Imatinib, Dipyridamole, Ranitidine, and Nalidixic Acid also belong to the group of direct inhibitors, disrupting MATE1-mediated transport through competitive binding to the substrate-binding site. These compounds provide specific tools for studying the molecular mechanisms underlying organic cation transport and the consequences of MATE1 inhibition on cellular transport processes.
Indirect inhibitors, including Probenecid, Gemfibrozil, and Diclofenac, modulate cellular pathways related to organic cation transport. They influence the expression and activity of renal organic anion transporters (OATs), leading to altered concentrations of endogenous substances and drugs that are substrates for both OATs and MATE1. This indirect modulation provides insights into the interconnected pathways governing the renal handling of organic ions and their impact on MATE1 function. In summary, the chemical class of MATE1 inhibitors encompasses a range of compounds that serve as valuable tools for investigating the intricate mechanisms governing organic cation transport. Whether through direct interference with the substrate-binding site or indirect modulation of related pathways, these inhibitors offer researchers the means to unravel the complexities of MATE1-mediated transport and its role in cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is a known inhibitor of MATE1. It competitively inhibits the transport of organic cations by MATE1, influencing the cellular uptake of various drugs and endogenous substances. This inhibition occurs through the direct interaction of cimetidine with the substrate-binding site of MATE1, preventing the translocation of substrates across the cell membrane and impacting their pharmacokinetics. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid acts as an indirect inhibitor of MATE1 by influencing cellular pathways related to organic cation transport. It inhibits the renal organic anion transporter (OAT) system, leading to altered concentrations of endogenous substances and drugs that are substrates for both OATs and MATE1. The indirect modulation of MATE1 by probenecid occurs through its impact on the interconnected pathways governing the renal handling of organic ions. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil inhibits MATE1-mediated transport by directly interacting with the transporter. It competitively hinders the binding of organic cations to MATE1, affecting the efflux of substrates from the cell. This direct inhibition alters the pharmacokinetics of various drugs and endogenous compounds, providing insights into the role of MATE1 in cellular transport processes and the potential consequences of its inhibition on substrate disposition. | ||||||
Famotidine | 76824-35-6 | sc-205691 sc-205691A | 500 mg 1 g | $64.00 $109.00 | ||
Famotidine serves as a direct inhibitor of MATE1 by competitively binding to its substrate-binding site. This interaction interferes with the transport of organic cations, impacting the cellular disposition of various drugs and endogenous substances. Famotidine's inhibition of MATE1 provides a valuable tool for studying the specific mechanisms underlying organic cation transport and its modulation in different physiological and pathological conditions. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $78.00 $233.00 $809.00 | 5 | |
Pyrimethamine is an inhibitor of MATE1 that directly interferes with the transporter's activity. By competitively binding to the substrate-binding site, pyrimethamine disrupts the translocation of organic cations across the cell membrane, influencing the pharmacokinetics of drugs and endogenous compounds that are substrates for MATE1. This direct inhibition highlights the potential impact of pyrimethamine on cellular transport processes mediated by MATE1. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $65.00 $262.00 | 2 | |
Gemfibrozil is an indirect inhibitor of MATE1 that influences cellular pathways related to organic cation transport. It modulates the expression and activity of renal organic anion transporters (OATs), leading to altered concentrations of endogenous substances and drugs that are substrates for both OATs and MATE1. Gemfibrozil's indirect modulation of MATE1 provides insights into the interconnected pathways governing the renal handling of organic ions. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
Dipyridamole acts as a direct inhibitor of MATE1 by competitively binding to its substrate-binding site. This interaction hinders the transport of organic cations, influencing the cellular disposition of various drugs and endogenous substances. Dipyridamole's direct inhibition of MATE1 offers a specific tool for investigating the molecular mechanisms underlying organic cation transport and its modulation in different physiological and pathological contexts. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib inhibits MATE1-mediated transport through a direct interaction with the transporter. By competitively binding to the substrate-binding site of MATE1, imatinib disrupts the translocation of organic cations, affecting the pharmacokinetics of drugs and endogenous compounds that are substrates for MATE1. This direct inhibition provides insights into the potential consequences of imatinib on cellular transport processes mediated by MATE1. | ||||||
Ranitidine | 66357-35-5 | sc-203679 | 1 g | $189.00 | ||
Ranitidine serves as a direct inhibitor of MATE1 by competitively binding to its substrate-binding site. This interaction interferes with the transport of organic cations, impacting the cellular disposition of various drugs and endogenous substances. Ranitidine's direct inhibition of MATE1 offers a specific tool for investigating the molecular mechanisms underlying organic cation transport and its modulation in different physiological and pathological contexts. | ||||||
Diclofenac acid | 15307-86-5 | sc-357332 sc-357332A | 5 g 25 g | $107.00 $292.00 | 5 | |
Diclofenac is an indirect inhibitor of MATE1 that modulates cellular pathways related to organic cation transport. It influences the expression and activity of renal organic anion transporters (OATs), leading to altered concentrations of endogenous substances and drugs that are substrates for both OATs and MATE1. Diclofenac's indirect modulation of MATE1 provides insights into the interconnected pathways governing the renal handling of organic ions. | ||||||