MARCH5 Inhibitors

A chemical class named MARCH5 inhibitorsrefers to compounds that can modulate the function of the MARCH5 protein, typically by interfering with its role in the ubiquitin-proteasome system. The members of this class achieve this effect through various mechanisms, given that MARCH5's role intersects multiple cellular pathways, particularly those concerning mitochondrial dynamics and quality control. These chemicals operate by either directly impeding the ubiquitination process crucial for protein degradation, which is the primary activity of MARCH5, or by modulating mitochondrial dynamics that MARCH5 is known to influence, such as fusion and fission processes. Additionally, some compounds can affect upstream regulatory pathways, such as NF-kB signaling, which might alter the expression levels of MARCH5 or related proteins. Others may target processes like apoptosis or mitochondrial biogenesis, both of which are integral to maintaining cellular homeostasis and are influenced by MARCH5's activity. Each member of this class, while not directly interacting with the MARCH5 protein, nonetheless contributes to the modulation of its function through a series of indirect but meaningful interactions within the cell.