MAPKAPK-2 Activators
MAPKAPK-2 activators belong to a specialized class of compounds that exert their influence on the Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK-2) enzyme. MAPKAPK-2, a serine/threonine kinase, plays a crucial role in cellular signaling pathways, particularly those associated with stress responses and inflammatory processes. The activation of MAPKAPK-2 is a multistep process, typically initiated by upstream signals from various cellular stressors, including cytokines, growth factors, and environmental stress. However, specific small molecules categorized as MAPKAPK-2 activators are designed to modulate or enhance the activity of this enzyme directly. These compounds possess a distinct molecular structure that enables them to bind selectively to MAPKAPK-2, promoting its activation and subsequent downstream signaling.
Structurally, MAPKAPK-2 activators are characterized by their ability to interact with key residues within the catalytic site of the enzyme, facilitating conformational changes that trigger its activation. This activation, in turn, leads to the phosphorylation of specific downstream substrates, often involved in cellular processes such as cytoskeletal dynamics, gene expression, and stress response modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates MAPKAPK-2 by inducing stress through inhibition of protein synthesis. This triggers the p38 MAPK pathway, leading to phosphorylation and activation of MAPKAPK-2, which in turn modulates downstream substrates involved in stress response. | ||||||
ERK Inhibitor II, FR180204 | 865362-74-9 | sc-203945 sc-203945A sc-203945B sc-203945C | 1 mg 5 mg 10 mg 50 mg | $110.00 $165.00 $239.00 $942.00 | 45 | |
FR 180204 is a selective ERK inhibitor that indirectly activates MAPKAPK-2. By suppressing the ERK pathway, it disrupts the inhibitory crosstalk between ERK and MAPKAPK-2, resulting in enhanced phosphorylation and activation of MAPKAPK-2 and its downstream stress-response substrates. | ||||||
4-Fluorobenzaldehyde | 459-57-4 | sc-238846 sc-238846A | 10 g 50 g | $31.00 $77.00 | ||
UR-13756 inhibits ERK5, indirectly activating MAPKAPK-2. By suppressing ERK5, it disrupts the inhibitory crosstalk between ERK5 and MAPKAPK-2, leading to increased phosphorylation and activation of MAPKAPK-2 and subsequent modulation of substrates involved in cellular stress responses. | ||||||