MAPKAP-1 (Mitogen-activated protein kinase-activated protein kinase 1) inhibitors belong to a class of compounds designed to target and inhibit the enzymatic activity of MAPKAP-1. MAPKAP-1 is a serine/threonine kinase that is activated downstream of MAPK (Mitogen-activated protein kinase) signaling pathways. It plays a crucial role in cellular responses to various extracellular stimuli, such as stress, inflammation, and cell proliferation. When activated, MAPKAP-1 phosphorylates and regulates the activity of various target proteins involved in diverse cellular processes, including cytoskeletal organization, gene expression, and cell cycle regulation.
Inhibiting MAPKAP-1 activity may modulate these cellular processes and impact cellular responses to external stimuli. Researchers are actively investigating MAPKAP-1 inhibitors to explore their mechanism of action and potential applications in cellular studies. These inhibitors can serve as valuable tools to dissect the functions of MAPKAP-1 in cellular signaling pathways and to gain new insights into its role in normal physiology and disease conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a well-known inhibitor that targets the upstream kinase p38 MAPK. While not specific to MAPKAP1, it indirectly inhibits the activation of MAPKAP1 by preventing p38 MAPK activation. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro-31-8220 is a broad-spectrum protein kinase inhibitor that targets several kinases, including MAPKAP1. | ||||||
ERK Inhibitor II, FR180204 | 865362-74-9 | sc-203945 sc-203945A sc-203945B sc-203945C | 1 mg 5 mg 10 mg 50 mg | $110.00 $165.00 $239.00 $942.00 | 45 | |
FR180204 is a potent and selective inhibitor of ERK signaling pathway, which indirectly affects the downstream MAPKAP1 activity. | ||||||
MK2 Inhibitor III | 724711-21-1 | sc-484523 sc-484523A | 2.5 mg 5 mg | $330.00 $400.00 | 1 | |
This is a small-molecule inhibitor specifically designed to target MAPKAP1 and block its kinase activity. | ||||||