Date published: 2026-4-16

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MAPKAP-1 Inhibitors

MAPKAP-1 (Mitogen-activated protein kinase-activated protein kinase 1) inhibitors belong to a class of compounds designed to target and inhibit the enzymatic activity of MAPKAP-1. MAPKAP-1 is a serine/threonine kinase that is activated downstream of MAPK (Mitogen-activated protein kinase) signaling pathways. It plays a crucial role in cellular responses to various extracellular stimuli, such as stress, inflammation, and cell proliferation. When activated, MAPKAP-1 phosphorylates and regulates the activity of various target proteins involved in diverse cellular processes, including cytoskeletal organization, gene expression, and cell cycle regulation.

Inhibiting MAPKAP-1 activity may modulate these cellular processes and impact cellular responses to external stimuli. Researchers are actively investigating MAPKAP-1 inhibitors to explore their mechanism of action and potential applications in cellular studies. These inhibitors can serve as valuable tools to dissect the functions of MAPKAP-1 in cellular signaling pathways and to gain new insights into its role in normal physiology and disease conditions.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 is a well-known inhibitor that targets the upstream kinase p38 MAPK. While not specific to MAPKAP1, it indirectly inhibits the activation of MAPKAP1 by preventing p38 MAPK activation.

Ro 31-8220

138489-18-6sc-200619
sc-200619A
1 mg
5 mg
$92.00
$245.00
17
(1)

Ro-31-8220 is a broad-spectrum protein kinase inhibitor that targets several kinases, including MAPKAP1.

ERK Inhibitor II, FR180204

865362-74-9sc-203945
sc-203945A
sc-203945B
sc-203945C
1 mg
5 mg
10 mg
50 mg
$110.00
$165.00
$239.00
$942.00
45
(2)

FR180204 is a potent and selective inhibitor of ERK signaling pathway, which indirectly affects the downstream MAPKAP1 activity.

MK2 Inhibitor III

724711-21-1sc-484523
sc-484523A
2.5 mg
5 mg
$330.00
$400.00
1
(0)

This is a small-molecule inhibitor specifically designed to target MAPKAP1 and block its kinase activity.