MAP-7 Inhibitors
Chemical inhibitors of microtubule-associated protein 7 (MAP-7) can affect the functional dynamics of microtubules by various mechanisms of action. Colchicine, nocodazole, vinblastine, podophyllotoxin, combretastatin A4, and S-Trityl-L-cysteine are compounds that bind to tubulin, the building block of microtubules, and inhibit its polymerization. This results in the destabilization and depolymerization of microtubules, impeding the stabilization role that MAP-7 plays. For instance, colchicine binds to tubulin and disrupts its assembly into microtubules, leading to their depolymerization. Nocodazole similarly inhibits tubulin polymerization, destabilizing microtubules. Vinblastine prevents tubulin from polymerizing, interfering with microtubule assembly, while podophyllotoxin binds to tubulin and inhibits its polymerization, disrupting microtubule dynamics essential for MAP-7's activity. Combretastatin A4 also targets tubulin, inhibiting its polymerization and affecting microtubule assembly. S-Trityl-L-cysteine acts as a microtubule-destabilizing agent that inhibits mitotic spindle function, which in turn can affect the stability and formation of microtubules and thus MAP-7's functionality.
On the other hand, agents like paclitaxel and peloruside A stabilize microtubules by preventing their disassembly, which can paradoxically inhibit functions that require microtubule dynamics, essential to MAP-7's role. Vincristine inhibits microtubule assembly by binding to tubulin dimers, which indirectly affects MAP-7's ability to stabilize microtubules. Eribulin binds to the growing ends of microtubules, inhibiting their elongation, which could impede the polymerization and stability enhancement role of MAP-7. Griseofulvin interferes with microtubule polymerization by binding to tubulin, which can inhibit the function of MAP-7. Lastly, noscapine binds to tubulin and modifies microtubule dynamics without directly inhibiting polymerization, influencing the microtubule stability that MAP-7 is known to promote. Each of these chemical inhibitors interacts with microtubule dynamics in a manner that can inhibit the stabilizing and assembly-promoting functions of MAP-7.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, a structural component of microtubules. MAP-7 is known to stabilize microtubules and promote microtubule polymerization. By disrupting tubulin assembly into microtubules, colchicine leads to microtubule depolymerization, which can inhibit the stabilizing function of MAP-7. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent. It binds to tubulin, inhibiting its polymerization, and thereby destabilizes microtubules. Since MAP-7 functions to stabilize microtubules, the action of nocodazole can lead to a functional inhibition of MAP-7 by destabilizing the microtubule network. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which paradoxically can inhibit functions that require microtubule dynamics. Since MAP-7 promotes microtubule stability and assembly, the action of paclitaxel can excessively stabilize microtubules, thereby inhibiting MAP-7's function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule assembly by binding to tubulin and can inhibit MAP-7 function indirectly. By preventing microtubule polymerization, vinblastine can alter microtubule dynamics, thereby inhibiting the stabilizing role of MAP-7 on microtubules. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin binds to the growing ends of microtubules, leading to the inhibition of their elongation. Since MAP-7 enhances microtubule polymerization and stability, the action of eribulin can indirectly inhibit the function of MAP-7 by inhibiting microtubule growth where MAP-7 is active. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits its polymerization into microtubules. MAP-7's role in microtubule stability would be indirectly inhibited by podophyllotoxin's action, which disrupts microtubule dynamics and assembly, processes essential for MAP-7 activity. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin and interfering with microtubule dynamics. As MAP-7 is involved in microtubule stabilization, griseofulvin's interference with microtubule polymerization can indirectly inhibit the function of MAP-7. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a microtubule-destabilizing agent that inhibits the mitotic spindle function. This compound can indirectly inhibit MAP-7 by altering the stability and formation of microtubules, thereby affecting the cellular processes that MAP-7 supports. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine binds to tubulin and alters microtubule dynamics without affecting microtubule polymerization directly. This alteration in microtubule dynamics can indirectly inhibit the function of MAP-7 by disrupting the microtubule stability that MAP-7 is known to enhance. | ||||||