MAP-6D1 Activators
MAP-6D1 Activators include a range of chemical compounds that directly or indirectly enhance the activity of MAP-6D1, a protein involved in stabilizing microtubules and regulating neuronal plasticity. Phorbol 12-myristate 13-acetate (PMA) and Forskolin lead to the activation of protein kinase C (PKC) and protein kinase A (PKA) respectively. Both PKC and PKA are capable of phosphorylating MAP-6D1 or its interacting partners, leading to enhanced activity in microtubule stabilization. Okadaic acid and Calyculin A are phosphatase inhibitors that prevent the dephosphorylation of proteins, indirectly sustaining MAP-6D1 in a phosphorylated state conducive to its functional activity.
AICAR activates AMP-activated protein kinase (AMPK), which can then phosphorylate MAP-6D1 or its associated proteins, thereby enhancing MAP-6D1's role in microtubule dynamics. In contrast, 5-Azacytidine and Trichostatin A (TSA) act epigenetically.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA directly activates protein kinase C (PKC) which can phosphorylate MAP-6D1. PKC-mediated phosphorylation enhances MAP-6D1's ability to stabilize microtubules and regulate neuronal plasticity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin stimulates adenylyl cyclase, leading to an increase in cAMP and activation of PKA. Active PKA can phosphorylate proteins associated with MAP-6D1, increasing its microtubule-stabilizing activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits protein phosphatase 1 and 2A, leading to increased phosphorylation levels within the cell. This indirectly maintains MAP-6D1 in a phosphorylated state, enhancing its function. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Similar to okadaic acid, Calyculin A inhibits phosphatases 1 and 2A, leading to sustained phosphorylation of MAP-6D1, which enhances its activity in microtubule stabilization and neuronal support. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK) which can phosphorylate MAP-6D1 or associated proteins, leading to the enhancement of MAP-6D1's microtubule-associated functions. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to hypomethylation and an active chromatin state that can increase the expression of proteins that interact with MAP-6D1, enhancing its function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA inhibits histone deacetylases, leading to hyperacetylation of histones and an open chromatin structure that may elevate the expression of proteins that enhance MAP-6D1's activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin raises intracellular Ca2+ levels, which can activate calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII can phosphorylate proteins that associate with MAP-6D1, enhancing its stabilization of microtubules. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which can lead to the activation of autophagy. This process can clear aggregated proteins and improve the cellular environment for MAP-6D1's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor which can activate GSK-3β through the inhibition of the PI3K/AKT pathway. GSK-3β can then phosphorylate tau, which interacts with MAP-6D1 to stabilize microtubules. | ||||||