MAB-5 Inhibitors
Chemical inhibitors of MAB-5 activity act through various pathways to modulate the protein's function. Indomethacin, by inhibiting cyclooxygenase, can reduce prostaglandin E2 levels, which in turn can decrease the activation of the Wnt signaling pathway, a key regulator of MAB-5 activity. Similarly, Quercetin can inhibit the PI3K/Akt pathway and thereby can influence Wnt signaling and MAB-5 activity. DAPT, as a gamma-secretase inhibitor, impedes Notch signaling, which interacts with Wnt signaling; this can lead to a decrease in Wnt-mediated regulation of MAB-5 activity. PD98059, which inhibits MEK in the MAPK/ERK pathway, can also modulate the Wnt pathway and hence can alter MAB-5 activity.
Further inhibition of MAB-5 can be achieved through the use of LY294002, a PI3K inhibitor, which can suppress PI3K/Akt pathway activity to reduce Wnt signaling. XAV-939 and IWR-1, both act by stabilizing Axin, a component of the Axin destruction complex involved in Wnt/β-catenin signaling, which can result in decreased MAB-5 activity. IWP-2 inhibits Wnt production by blocking the activity of Porcupine, necessary for Wnt secretion, can lead to reduced MAB-5 activity. JW55 can inhibit β-catenin mediated transcription within the Wnt signaling pathway, which can decrease MAB-5 activity. LGK-974, another Porcupine inhibitor, prevents Wnt ligand activity and secretion, which can reduce the regulatory effects on MAB-5. PNU-74654 disrupts the β-catenin/TCF interaction, leading to inhibition of Wnt/β-catenin signaling and subsequent reduction in MAB-5 activity. Lastly, FH535 can inhibit β-catenin and PPAR signaling, which can suppress Wnt signaling and consequently MAB-5 activity. Each chemical, by targeting different components or modulators of the Wnt pathway, can contribute to the regulation of MAB-5 activity through a network of signaling interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin is a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase (COX), which could reduce prostaglandin E2 (PGE2) levels. Elevated PGE2 can activate the Wnt signaling pathway, which is known to be involved in the regulation of MAB-5 activity. Thus, by lowering PGE2, Indomethacin may decrease Wnt pathway activity, leading to the inhibition of MAB-5. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that has been shown to inhibit the PI3K/Akt pathway, which is interconnected with Wnt signaling. Since Wnt signaling can regulate MAB-5 activity, inhibition of PI3K/Akt by Quercetin could reduce Wnt-mediated MAB-5 activity. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is a gamma-secretase inhibitor that impedes the Notch signaling pathway. Notch can interact with Wnt signaling, which is relevant to MAB-5 regulation. Inhibiting Notch signaling with DAPT may diminish Wnt signaling output, thereby inhibiting MAB-5 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK, which is a part of the MAPK/ERK pathway. The MAPK/ERK pathway can modulate Wnt signaling. By inhibiting MEK, PD98059 could limit Wnt pathway activity, potentially inhibiting MAB-5 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, which is upstream of Akt. By inhibiting PI3K, LY294002 can suppress the PI3K/Akt pathway, thereby potentially reducing Wnt signaling and consequently inhibiting MAB-5 activity. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939 is a tankyrase inhibitor which stabilizes Axin by preventing its poly-ADP-ribosylation, leading to the inhibition of the Wnt/β-catenin signaling pathway. As Wnt signaling can regulate MAB-5, inhibiting Wnt with XAV-939 could result in reduced MAB-5 activity. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1 is an inhibitor of Wnt response by stabilizing the Axin destruction complex, leading to decreased β-catenin signaling. As β-catenin is a component of the Wnt pathway that can regulate MAB-5 activity, inhibition by IWR-1 could decrease MAB-5 activity. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 inhibits Wnt production by blocking the activity of Porcupine, an O-acyltransferase involved in Wnt processing and secretion. Reduced Wnt signaling due to IWP-2 could lead to the inhibition of MAB-5 activity. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55 is an inhibitor of the β-catenin responsive transcription, which is mediated by the Wnt signaling pathway. By inhibiting β-catenin-mediated transcription, JW55 could indirectly inhibit MAB-5 activity. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
LGK-974 is a Porcupine inhibitor which prevents the secretion and activity of Wnt ligands. As Wnt signaling is implicated in the regulation of MAB-5, inhibition by LGK-974 can lead to decreased MAB-5 activity. | ||||||