The term LOC644838 Inhibitors designates a specialized class of chemical compounds meticulously crafted to modulate the activity of LOC644838, a molecular target currently under scientific investigation. These inhibitors are developed through principles rooted in medicinal chemistry, emphasizing their capacity to selectively interfere with the normal functions of LOC644838 within cellular processes. The structural features of LOC644838 Inhibitors undergo a thorough optimization process, often incorporating computational modeling and structure-activity relationship studies, to ensure their molecular configurations are precisely tailored for effective binding to the target.
The significance of LOC644838 Inhibitors lies in their potential to disrupt the biochemical activities associated with LOC644838, a molecular entity believed to play a role in various biological pathways. Researchers in this field delve into the three-dimensional structure of LOC644838 and its binding interactions with inhibitors, aiming to unravel the intricate molecular mechanisms underlying inhibition. The study of LOC644838 Inhibitors contributes to a broader understanding of cellular processes, offering insights into the roles played by LOC644838 in diverse biological pathways and expanding our knowledge of the regulatory networks governing cellular activities. This research not only advances our comprehension of the molecular intricacies surrounding LOC644838 but also contributes to the broader scientific understanding of molecular targets and their involvement in fundamental cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to inhibit global transcription by affecting RNA Polymerase II activity, which could lead to reduced lncRNA transcription. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid can induce degradation of RNA polymerase II, potentially decreasing RNA synthesis including lncRNAs. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases, which are important for RNA Polymerase II phosphorylation and transcriptional elongation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA, inhibiting RNA polymerase and thus transcription, potentially reducing lncRNA levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
This toxin from Amanita mushrooms inhibits RNA polymerase II, which is crucial for mRNA and lncRNA synthesis. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA Polymerase II by blocking the transition from initiation to elongation, reducing mRNA synthesis. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine is a cytidine analogue that can get incorporated into RNA, potentially affecting RNA stability and lncRNA function. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B targets the spliceosome, potentially disrupting splicing of lncRNAs and other RNAs. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits the export of RNA from the nucleus to the cytoplasm, which could affect the maturation and function of lncRNAs. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 inhibits BET bromodomain proteins, affecting chromatin structure and potentially downregulating transcription of lncRNAs. | ||||||