Date published: 2025-10-26

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LOC284023 Inhibitors

Inhibitors such as Wortmannin and LY294002 act upon phosphoinositide 3-kinases (PI3K), pivotal regulators of intracellular signaling pathways related to growth, proliferation, and survival. Inhibition of PI3K leads to disrupted downstream signaling which can impact the function and regulation of proteins. Rapamycin, binding to the mechanistic target of rapamycin (mTOR), influences protein synthesis and degradation, thereby possibly altering the turnover rate of proteins, including LOC284023. Compounds targeting the MAPK/ERK pathway such as U0126, SB203580, and PD98059, can lead to altered gene expression profiles and modify responses to cellular stress, which can have a downstream effect on the function or stability of various proteins. Inhibitors of the JNK pathway, like SP600125, are known to affect the cellular stress response, which might influence the expression and function of proteins involved in response to environmental changes.

Proteasome inhibitors like Bortezomib and MG132 disrupt the degradation of ubiquitin-tagged proteins, potentially leading to increased levels of certain proteins, which can interfere with normal protein turnover and function. ZM447439, by inhibiting Aurora kinases, affects chromosomal alignment and segregation during mitosis, which can influence proteins associated with cell division. Dasatinib, through its inhibition of Src family kinases, has a broad impact on cell adhesion, growth, and differentiation signaling pathways, all of which could modulate protein function and stability. Gefitinib, an EGFR tyrosine kinase inhibitor, affects growth factor signaling, which is crucial for regulating protein expression and function.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Inhibits PI3K, affecting signaling pathways that can alter protein function and localization.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Binds to mTOR, potentially affecting protein synthesis and degradation pathways.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

Inhibits PI3K, leading to modulation of downstream proteins and possibly affecting protein stability.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

Inhibits MEK, which can alter MAPK pathway signaling affecting protein expression.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

Inhibits p38 MAPK, potentially impacting stress response and protein modification.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

Inhibits MEK, which can lead to changes in protein expression via the MAPK pathway.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

Inhibits JNK, potentially affecting protein expression and cellular stress responses.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Inhibits proteasome, affecting protein degradation pathways that can influence protein levels.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

Inhibits proteasome, potentially leading to altered protein turnover and function.

ZM-447439

331771-20-1sc-200696
sc-200696A
1 mg
10 mg
$150.00
$349.00
15
(1)

Inhibits Aurora kinase, potentially affecting protein-related processes in mitosis.