LMBRD1 Activators
Chemical activators of the protein LMBRD1 can facilitate its function in the cellular uptake of cobalamin, which is vital for various metabolic processes. S-Adenosylmethionine (SAM) is one such activator that, by serving as a universal methyl donor, can indirectly enhance LMBRD1 activity. This is because SAM's role in methylation reactions can lead to an increased requirement for cobalamin, thereby necessitating LMBRD1's role in its transport. Similarly, active forms of vitamin B12, such as 5-Deoxyadenosylcobalamin and Methylcobalamin, are directly related to enzymatic reactions that depend on cobalamin. Their presence in the cell can signal a need for cobalamin, thus stimulating the activity of LMBRD1 to meet this demand. Furthermore, Hydroxocobalamin, another vitamin B12 variant, can also be converted into active coenzyme forms within the body, supporting the need for LMBRD1 in cobalamin processing. Betaine also plays a role as it contributes to the conversion of homocysteine to methionine, a reaction requiring cobalamin, which, in turn, suggests a role for LMBRD1 in cobalamin transport.
Additionally, the presence of nitric oxide donors such as Sodium nitroprusside can lead to improved nutrient delivery, including cobalamin, by causing vasodilation and increased blood flow. This can indirectly necessitate an increase in LMBRD1 activity to handle the enhanced cobalamin uptake. Cobalt chloride, through the mimicry of hypoxic conditions, can activate hypoxia-inducible factors that influence cobalamin metabolism, possibly leading to a rise in LMBRD1 activity to accommodate altered cobalamin handling under such conditions. Glutathione, as an antioxidant, influences the detoxification pathways and metabolism of vitamins, which may affect the transport and utilization of cobalamin, thereby indirectly involving LMBRD1. These chemicals, by affecting the cellular homeostasis and metabolism of cobalamin, engage the functional role of LMBRD1 in transporting and processing this vital nutrient.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
S-Adenosylmethionine (SAM) serves as a methyl donor in numerous methylation reactions, including DNA, RNA, and proteins. LMBRD1 is involved in the cellular uptake of cobalamin (vitamin B12). Proper function of LMBRD1 is required for the synthesis of methionine from homocysteine, a reaction that is also dependent on methylcobalamin, a form of vitamin B12. SAM can enhance this metabolic pathway by providing the necessary methyl groups, which may lead to an increased demand for cobalamin uptake and indirectly increase LMBRD1 function to meet this demand. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Nitric oxide (NO) serves as a signaling molecule that can modulate various biological processes, including the intracellular trafficking of vitamins and minerals. Sodium nitroprusside, as a donor of NO, can lead to the vasodilation and increased blood flow, which may enhance nutrient delivery to cells, including cobalamin. This increased availability of cobalamin could indirectly necessitate greater activity of LMBRD1 to transport cobalamin into cells. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine serves as a methyl donor in the conversion of homocysteine to methionine, a reaction that is also dependent on cobalamin as a cofactor. By promoting methionine synthesis, betaine could indirectly enhance the demand for cobalamin and, consequently, the functional activation of LMBRD1 to facilitate cobalamin uptake for this pathway. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Cyanocobalamin is a synthetic form of vitamin B12 commonly used in supplements. It can be converted into active forms of cobalamin within the body, indirectly increasing the requirement for LMBRD1 activity to transport and process cobalamin into its active forms. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Glutathione is an antioxidant that can influence various metabolic pathways, including those involved in the detoxification of cells and the metabolism of vitamins and minerals. Elevated glutathione levels may enhance the cellular capacity to handle oxidative stress, potentially affecting the transport and utilization of cobalamin and thus indirectly promoting the functional activation of LMBRD1. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Cobalt chloride can mimic hypoxic conditions in cells, leading to the activation of various hypoxia-inducible factors (HIFs). This activation can affect the metabolism and transport of several cofactors and vitamins, including cobalamin. Indirectly, this could increase the activity of LMBRD1, as the protein is involved in the cellular uptake and trafficking of cobalamin. | ||||||