LIAS Activators
LIAS activators encompass a group of compounds that indirectly influence the activity of LIAS by enhancing mitochondrial function or providing necessary substrates and cofactors for the biosynthesis of lipoic acid. Compounds such as Coenzyme Q10 and NADH play crucial roles in maintaining the electron transport chain and ATP production, which are vital for the energy-dependent processes LIAS is involved in. The presence of alpha-ketoglutarate and succinyl-CoA is particularly important as they are part of the TCA cycle and directly impact the availability of key substrates for LIAS. Substances like thiamine pyrophosphate and riboflavin are essential for the proper functioning of enzymes that feed into the mitochondrial processes, thereby supporting LIAS activity indirectly. L-Carnitine's role in fatty acid transport into the mitochondria ensures a steady supply of acetyl-CoA for the TCA cycle, which in turn could facilitate the LIAS-mediated synthesis of lipoic acid.
The micronutrients like copper and manganese are critical for maintaining the integrity of the mitochondrial environment. Copper can boost the electron transport chain, while manganese is vital for antioxidant defense within the mitochondria. This can help sustain an environment in which LIAS can function optimally. Magnesium's role as a cofactor for ATP synthesis-related enzymes also highlights its indirect support for LIAS activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 is integral to the electron transport chain. By sustaining mitochondrial respiration, it ensures an adequate supply of ATP, which is necessary for LIAS activity and the biosynthesis of lipoic acid. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-ketoglutarate is a key molecule in the tricarboxylic acid (TCA) cycle. Its presence can stimulate the TCA cycle, providing more succinyl-CoA, a substrate necessary for the enzymatic reaction catalyzed by LIAS. | ||||||
NADH disodium salt | 606-68-8 | sc-205762 sc-205762A | 500 mg 1 g | $91.00 $127.00 | 3 | |
NADH is essential for the electron transport chain to maintain mitochondrial membrane potential and ATP synthesis. A high NADH/NAD+ ratio can signify robust mitochondrial activity which is a conducive environment for LIAS function. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions can act as cofactors for various enzymes. Copper (II) sulfate may enhance electron transport chain activity, indirectly supporting the mitochondrial environment in which LIAS operates. | ||||||
Manganese(II) sulfate monohydrate | 10034-96-5 | sc-203130 sc-203130A | 100 g 500 g | $41.00 $107.00 | ||
Manganese ions are important for the function of mitochondrial superoxide dismutase. By reducing oxidative stress in mitochondria, manganese (II) sulfate can maintain an optimal environment for LIAS activity. | ||||||
Thiamine pyrophosphate | 154-87-0 | sc-215966 sc-215966A sc-215966B sc-215966C sc-215966D | 1 g 5 g 25 g 100 g 1 kg | $33.00 $97.00 $290.00 $1149.00 $6024.00 | 1 | |
Thiamine pyrophosphate is a coenzyme for the enzyme pyruvate dehydrogenase which generates acetyl-CoA, a substrate that enters the TCA cycle. Enhanced activity of this enzyme can increase the availability of substrates for the TCA cycle, thereby supporting LIAS function. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin is a precursor to FAD, a cofactor used by many oxidoreductases, including those in the electron transport chain. Increased FAD can enhance mitochondrial respiration, indirectly supporting LIAS activity. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine facilitates the transport of fatty acids into mitochondria for beta-oxidation, which produces acetyl-CoA for the TCA cycle. By enhancing the availability of acetyl-CoA, L-Carnitine indirectly supports the activity of LIAS. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium ions are essential cofactors for many enzymatic reactions, including those in the TCA cycle and ATP synthesis. By ensuring the proper function of these enzymes, magnesium sulfate can indirectly enhance the environment for LIAS activity. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $41.00 $96.00 | ||
Pyruvate enters the mitochondria and contributes to the acetyl-CoA pool after conversion by pyruvate dehydrogenase. This supports the TCA cycle, which is tightly linked to the mitochondrial environment where LIAS is active. | ||||||