LHR Activators
Chemical activators of LHR, or Luteinizing hormone receptor, primarily function by influencing the cyclic AMP (cAMP) pathway that LHR is intrinsically involved in as a G-protein coupled receptor (GPCR). Forskolin and IBMX, for instance, can modulate this pathway by increasing cAMP levels through the activation of adenylate cyclase and through the inhibition of phosphodiesterases, respectively. This increase in cAMP levels can then lead to increased LHR activity.
Additionally, several inhibitors of specific phosphodiesterase (PDE) subtypes, such as Rolipram, Vinpocetine, Zardaverine, Cilostamide, Siguazodan, Etazolate, Trequinsin, Milrinone, Pimobendan, and Cilomilast, can increase cAMP levels by specifically inhibiting the PDE subtype that they target. This prevents the breakdown of cAMP, leading to an increase in its intracellular concentration, which can then lead to an increase in LHR activity. These compounds, therefore, provide various ways to modulate the activity of LHR through their effect on cAMP levels.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can activate adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. cAMP acts as a second messenger in the G-protein coupled receptor (GPCR) signaling pathway that LHR is a part of, leading to increased LHR activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP breakdown, IBMX can increase cAMP concentration, leading to increased LHR activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor. PDE4 is one of the enzymes that break down cAMP. Thus, Rolipram can increase cAMP levels, leading to increased LHR activity. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine is a selective PDE1 inhibitor. By inhibiting PDE1, it can increase cAMP levels, leading to increased LHR activity. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a dual PDE3/4 inhibitor. It increases cAMP levels, leading to increased LHR activity. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $92.00 $357.00 | 16 | |
Cilostamide is a PDE3 inhibitor. By inhibiting PDE3, it can increase cAMP levels, leading to increased LHR activity. | ||||||
Siguazodan | 115344-47-3 | sc-201201 sc-201201A | 5 mg 25 mg | $100.00 $398.00 | ||
Siguazodan is a PDE3 inhibitor. It increases cAMP levels, leading to increased LHR activity. | ||||||
Etazolate Hydrochloride | 35838-58-5 | sc-201186 sc-201186A | 5 mg 25 mg | $61.00 $255.00 | 5 | |
Etazolate is a PDE4 inhibitor. It increases cAMP levels, leading to increased LHR activity. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a PDE3 inhibitor. It increases cAMP levels, leading to increased LHR activity. | ||||||
Cilomilast | 153259-65-5 | sc-483188 | 5 mg | $132.00 | 1 | |
Cilomilast is a PDE4 inhibitor. It increases cAMP levels, leading to increased LHR activity. | ||||||