Lamin B2 Inhibitors
Lamin B2, a member of the lamin family of proteins, plays a critical role in maintaining the structural integrity and stability of the cell nucleus. As a major component of the nuclear lamina, Lamin B2 contributes to the organization and support of the nuclear envelope, which surrounds and protects the genetic material within the nucleus. Furthermore, Lamin B2 is involved in various nuclear functions, including chromatin organization, gene regulation, and DNA replication. Its presence at the nuclear periphery provides structural support for the anchoring of chromatin and regulatory complexes, influencing gene expression and cellular processes such as DNA replication and repair. Additionally, Lamin B2 has been implicated in nuclear envelope dynamics during cell division, where it participates in the disassembly and reassembly of the nuclear envelope, ensuring proper segregation of genetic material.
Inhibition of Lamin B2 can disrupt nuclear architecture and function, leading to aberrant cellular processes and pathological consequences. Several mechanisms of inhibition have been proposed, including interference with Lamin B2 expression, post-translational modifications, or protein-protein interactions. For instance, downregulation of Lamin B2 expression through genetic or pharmacological means can result in structural defects in the nuclear envelope, affecting nuclear morphology and integrity. Additionally, inhibition of Lamin B2 function may impair its interaction with chromatin and nuclear envelope proteins, disrupting nuclear organization and function. Furthermore, targeting the pathways involved in Lamin B2 regulation or its association with other nuclear components could provide alternative strategies for inhibiting its activity and investigating its role in cellular physiology and disease pathology. Overall, understanding the mechanisms of Lamin B2 inhibition is essential for elucidating its functional significance in nuclear biology and exploring its ability as a target in various pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin is a competitive inhibitor of HMG-CoA reductase, a key enzyme in the mevalonate pathway. By inhibiting this pathway, simvastatin reduces the synthesis of cholesterol and is implicated in modulating Lamin B2 through downstream effects. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B functions as a nuclear export inhibitor by binding to CRM1, preventing the export of various proteins from the nucleus. This inhibition of nuclear export may impact the localization and function of Lamin B2 within the nuclear envelope. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is a derivative of vitamin A that can influence gene expression. It has been reported to regulate the expression of lamins, potentially affecting Lamin B2 levels and localization through transcriptional mechanisms. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin is an antibiotic that induces DNA damage by causing single- and double-strand breaks. This genotoxic effect may lead to alterations in nuclear architecture, potentially impacting the structure and function of Lamin B2. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, causing cell cycle arrest. The alteration of the cytoskeleton and cell cycle dynamics may indirectly influence the nuclear envelope and Lamin B2 organization. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin, an anthracycline antibiotic, intercalates with DNA and inhibits topoisomerase II, leading to DNA damage. The resulting cellular stress and DNA alterations may have downstream effects on nuclear envelope components, including Lamin B2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, impacting cell growth and proliferation. The modulation of mTOR signaling can affect various cellular processes, potentially influencing the expression and function of nuclear envelope proteins such as Lamin B2. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is a pyrimidine analog that disrupts nucleotide synthesis. Its impact on DNA replication and repair pathways may lead to alterations in nuclear structure and function, potentially affecting Lamin B2 dynamics within the nuclear envelope. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates with DNA and inhibits RNA polymerase, causing transcriptional inhibition. The disruption of RNA synthesis can have widespread effects on cellular processes, potentially influencing the expression and regulation of nuclear envelope proteins like Lamin B2. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits topoisomerase II, resulting in DNA damage and cell cycle arrest. The genotoxic effects of etoposide may impact nuclear structure and function, potentially influencing the organization and dynamics of nuclear envelope proteins, including Lamin B2. | ||||||