laeverin_4833403I15Rik Activators
Laeverin activators are chemical compounds that can directly or indirectly enhance the functional activity of laeverin, a membrane protein. The mechanisms of action of these activators converge on the common pathway of cAMP production and protein kinase A (PKA) activation. For instance, Epinephrine and Prostaglandin E2 (PGE2) are adrenergic and prostaglandin receptor agonists respectively that activate their respective receptors, leading to increased cAMP production. Increased cAMP can then activate PKA, potentially enhancing the function of laeverin.
Furthermore, a number of selective phosphodiesterase inhibitors like IBMX, Rolipram, Vinpocetine, Cilostamide, Zardaverine, Milrinone, Etazolate, Piclamilast, and BRL50481 enhance laeverin function by increasing cAMP levels in the cell. Phosphodiesterases are enzymes that degrade cAMP; thus, their inhibition results in increased cAMP levels. Higher cAMP levels can activate PKA, which could phosphorylate and enhance the functional activity of laeverin. Forskolin, another laeverin activator, directly activates adenylate cyclase, increasing the levels of cAMP in the cell and subsequently leading to PKA activation and enhanced laeverin function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is an adrenergic receptor agonist that activates adrenergic receptors, leading to increased cAMP production. Laeverin, being a membrane protein, could be influenced by the changes in cellular signaling, leading to enhanced function. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) is a potent activator of the EP2 and EP4 receptors, leading to an increase in cAMP production. Through this specific pathway, the cellular signaling can influence the function of laeverin. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By inhibiting phosphodiesterases, IBMX increases cAMP levels, which can activate PKA and subsequently enhance laeverin function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase-4, which leads to increased intracellular cAMP levels. cAMP can activate PKA, which could enhance the functional activity of laeverin. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine is a selective phosphodiesterase-1 inhibitor, which prevents the degradation of cAMP. Increased cAMP levels can activate PKA, potentially leading to enhanced laeverin function. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $92.00 $357.00 | 16 | |
Cilostamide is a selective phosphodiesterase-3 inhibitor. By inhibiting PDE3, cilostamide increases cAMP levels, which can activate PKA and potentially enhance laeverin function. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a dual inhibitor of phosphodiesterase-3 and -4 leading to increased cAMP levels. Higher cAMP levels can activate PKA, which can phosphorylate and enhance the functional activity of laeverin. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a selective phosphodiesterase-3 inhibitor, which leads to increased intracellular cAMP levels. Higher cAMP levels can activate PKA, which can enhance the function of laeverin. | ||||||
Etazolate Hydrochloride | 35838-58-5 | sc-201186 sc-201186A | 5 mg 25 mg | $61.00 $255.00 | 5 | |
Etazolate is a phosphodiesterase-4 inhibitor, increasing cAMP levels in the cell. Increased cAMP can activate PKA, leading to enhanced laeverin function. | ||||||
Piclamilast | 144035-83-6 | sc-478653 | 5 mg | $300.00 | ||
Piclamilast is a selective phosphodiesterase-4 inhibitor, which leads to increased cAMP levels. Higher cAMP levels can activate PKA, potentially enhancing the function of laeverin. | ||||||