Ku-70 Inhibitors

Ku-70 Inhibitors encompass a diverse array of compounds designed to intricately modulate the function or interaction of Ku-70, a crucial component of the DNA repair machinery. The carefully selected inhibitors outlined above target various aspects of DNA repair processes associated with Ku-70, showcasing the multifaceted approaches within this chemical class. NU7441, a direct DNA-PK inhibitor, disrupts the catalytic subunit of DNA-PK, impacting Ku-70-mediated DNA repair pathways. Mirin, another DNA-PK inhibitor, disrupts the interaction between DNA-PK and Ku, leading to impaired DNA repair processes involving Ku-70. VX-984 and NU7026 are additional DNA-PK inhibitors influencing Ku-70-associated DNA repair by disrupting DNA-PK activity. SCR7, a Ligase IV inhibitor, is noteworthy for its indirect impact on Ku-70. By disrupting non-homologous end joining (NHEJ) repair, it affects Ku-70, a key component of the NHEJ machinery. Wortmannin, a PI3 kinase inhibitor, is an intriguing member of this class that may indirectly influence Ku-70-associated DNA repair pathways. KU-0060648 and CC-115 are DNA-PK inhibitors with effects on Ku-70-mediated DNA repair processes, specifically targeting the kinase activity of DNA-PK, where Ku-70 plays a crucial role. CC-122 and IC86621, identified as PARP inhibitors, contribute to the landscape of Ku-70 modulation by disrupting poly(ADP-ribose) polymerase activity. This interference impacts Ku-70-mediated DNA repair mechanisms, showcasing the interconnectedness of various components in the DNA repair cascade. NU1025, another PARP inhibitor, and AZD7648, a DNA-PK inhibitor, further expand the spectrum of Ku-70 Inhibitors.