KRTAP5-2 Inhibitors
KRTAP5-2 inhibitors encompass a variety of chemical compounds that act to disrupt the normal function of the Keratin Associated Protein 5-2 (KRTAP5-2) by targeting the disulfide bond formation it mediates in hair shaft proteins. Disulfide bonds are crucial for the structural integrity and rigidity of hair, and KRTAP5-2 is an integral part of this biochemical process. Compounds like N-Ethylmaleimide (NEM), Dithiothreitol (DTT), and Iodoacetamide specifically target cysteine residues which are essential for the formation of these critical disulfide bridges. NEM acts by modifying these residues, DTT by reducing disulfide bonds, and Iodoacetamide by alkylating cysteines, all resulting in the inhibition of KRTAP5-2's ability to contribute to hair protein structure.
Moreover, heavy metals such as Cadmium chloride and Lead(II) acetate function as inhibitors by interacting with the thiol groups on cysteine residues, potentially disrupting the disulfide bond formation. These metal ions can bind to the sulfhydryl groups and may either block the active site or change the protein conformation, which can inhibit the function of KRTAP5-2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO is a solvent that can penetrate biological membranes and may inhibit KRTAP5-2 by altering the conformation of keratin proteins within hair follicles, possibly affecting the disulfide bond formation crucial for KRTAP5-2's function in hair structure. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
NEM is a sulfhydryl-reactive compound that can inhibit KRTAP5-2 by modifying cysteine residues, preventing disulfide bond formation in keratin-associated proteins, which is essential for the structural stability provided by KRTAP5-2. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $250.00 | 1 | |
Iodoacetamide is an alkylating agent that can inhibit KRTAP5-2 by irreversibly modifying cysteine residues, which are critical for the protein's function in cross-linking keratin fibers in hair. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium chloride is a heavy metal salt that can inhibit KRTAP5-2 by binding to sulfhydryl groups, potentially disrupting protein-protein interactions and disulfide bond formation facilitated by KRTAP5-2. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $83.00 | ||
Lead(II) acetate is another heavy metal compound that can inhibit KRTAP5-2 by binding to thiol groups on cysteine residues, which might inhibit the protein's ability to form disulfide bonds in keratin structures. | ||||||
Sodium arsenite, 0.1N Standardized Solution | 7784-46-5 | sc-301816 | 500 ml | $130.00 | 4 | |
Sodium arsenite can inhibit KRTAP5-2 by binding to vicinal thiols, thereby interfering with disulfide bond formation and potentially disrupting KRTAP5-2's role in hair keratin stabilization. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $49.00 $229.00 | 5 | |
Ethacrynic acid is a reactive electrophilic compound that can inhibit KRTAP5-2 by forming adducts with cysteine residues, altering the structure and function of keratin-associated proteins like KRTAP5-2. | ||||||